动态检测血清胸腺素β4对慢性肝衰竭预后的判断价值  

Predictable value of dynamic changes of serum thymosin β4 on prognosis in patients with chronic liver failure

作　　者：刘莹[1] 韩涛[1] 朱争艳[1] 刘华[1] 郭震[1] 李莹[1] 肖时湘[1] 李岩[1] 

机构地区：[1]天津市第三中心医院肝内科天津肝胆病研究所天津人工细胞重点实验室,300170

出　　处：《传染病信息》2011年第4期215-217,223,共4页Infectious Disease Information

基　　金：国家重点基础研究发展计划(973计划)专项(2007CB-512801);国家"十一五"科技重大专项(2008ZX10002-005);天津市卫生局重点攻关资助项目(07KG9)

摘　　要：目的探讨血清胸腺素β4的动态变化情况对慢性肝衰竭患者预后的判断价值。方法采用酶联免疫吸附测定法检测39例肝衰竭患者血清胸腺素β4的水平。结果 39例肝衰竭患者按照预后不同分为生存组及死亡组,生化指标TBIL(P=0.018)、凝血酶原时间国际标准化比值(international normalized ratio,INR)(P=0.000)、血清胸腺素β4(P=0.003)在2组间的差异具有统计学意义。Logistic回归分析显示,INR(P=0.033)和胸腺素β4水平(P=0.034)是影响肝衰竭患者预后的危险因素。在动态观察中,生存组患者血清胸腺素β4升高明显,INR下降明显。结论监测血清胸腺素β4和INR水平的动态变化有利于判断肝衰竭患者的预后。Objective To investigate the value of dynamic changes of serum thymosin β4 on prognosis in patients with chronic liver failure. Methods Serum thymosin β4 levels were measured by enzyme-linked immunosorbent assay in 39 patients with liver failure. Results Totally 39 patients with liver failure were divided into survivor group and non-survivor group according to their different prognosis. Before treatment, the difference of TBIL （P=0.018）, international normalized ratio （INR） （P=0.000） and serum thymosis β4 （P=0.003） between survivors and non-survivors had the statistical significance. Logistic regression analysis showed that INR （P=0.033） and serum thymosis β4 （P=0.034） were the risk factors influencing the prognosis in patients with liver failure. In dynamic observation, significant increase in thymosin β4 values and decrease in INR levels were found in survivor group. Conclusion Dynamic changes of serum thymosin β4 and INR levels can predict the prognosis in patients with liver failure.

关 键 词：肝功能衰竭 血清胸腺素β4 国际标准化比值 预后 

分 类 号：R575.3[医药卫生—消化系统]