磺化异麦芽寡聚糖对肝癌细胞增殖、细胞周期和凋亡的影响  

The Effects of IMOS on HCC Proliferation,Cell Cycle and Apoptosis

作　　者：肖春丽[1] 陶中华[1] 万金良[1] 吴伟忠[1] 

机构地区：[1]复旦大学附属中山医院肝癌研究所,上海200032

出　　处：《中国临床医学》2011年第4期419-421,共3页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金(编号:81071904)

摘　　要：目的:探讨磺化异麦芽寡聚糖(isomalto oligosaccharide sulfate,IMOS)对肝癌细胞增殖、细胞周期和细胞凋亡的影响。方法:分别采用细胞计数、荧光面积和流式细胞仪评价IMOS对肝癌细胞增殖、细胞周期和细胞凋亡的影响。结果:在体外,IMOS能显著抑制HCCLM3、HepG2、Be-l7402和HCCLM3-RFP细胞的增殖并诱导细胞凋亡。结论:IMOS是一种潜在的抗肝癌药物,可在人肝癌裸鼠移植模型中进一步开展抗肝癌疗效的评价。Objective：We explored the effects of isomalto oligosaccharide sulfate（IMOS） on cell proliferation,cell cycle and apoptosis in HCC cell lines.Methods：The effects of IMOS on HCC proliferation,cell cycle and apoptosis were assessed by cell counting,fluorescent area and flow cytometry,respectively.Results： IMOS markedly inhibited cell proliferation and induced cell apoptosis of HCCLM3,HepG2,Bel-7402 and HCCLM3-RFP cells in vitro.Conclusions： IMOS is a potential anti-HCC candidate and worth studying further in xenograft nude mice models in vivo.

关 键 词：磺化异麦芽寡聚糖 肝癌 增殖 细胞周期 凋亡 

分 类 号：R735.7[医药卫生—肿瘤]