水介质中Yb(OTf)_3催化下喹唑啉酮衍生物的绿色合成  

A Clean Synthesis of Quinazolinone Derivatives in Water Catalyzed by Yb(OTf)_3

作　　者：王树良[1] 盛洁[1] 屠树江[1] 王香善[1] 

机构地区：[1]徐州师范大学化学化工学院,徐州221116

出　　处：《有机化学》2011年第9期1522-1526,共5页Chinese Journal of Organic Chemistry

基　　金：江苏省高校自然科学基金(No.08KJD150019);江苏省"青蓝工程"创新团队(No.08QLT001)资助项目

摘　　要：在水介质中,醛或酮首先和邻氨基苯甲酰肼反应形成腙;在1 mol%Yb(OTf)3催化下,再与另外一分子醛或酮反应,构建一系列不同取代的喹唑啉酮衍生物.该方法具有中性反应条件、产率高(80%～94%)、操作简单和环境友好等优点.产物的结构通过IR,1H NMR和HRMS表征.Using water as a green reaction media,aldehydes or ketones react with 2-aminobenzohydrazide to give hydrazone firstly,and then a series of quinazolinone derivatives are obtained by the reaction of the hydrazone with another molecule of aldehyde or ketone catalyzed by 1 mol% Yb（OTf）3.This method provides several advantages such as neutral conditions,high yields（80%～94%）,simple work-up and environmental benignity.The structures were established by spectroscopic data of IR,1H NMR and HRMS techniques.

关 键 词：邻氨基苯甲酰肼 喹唑啉酮 水 Yb(OTf)3 

分 类 号：O626.2[理学—有机化学]