依达拉奉对血管性痴呆大鼠脑组织β淀粉样蛋白、Tau蛋白表达的影响  

Influence of edaravone on expressions of beta amyloids and Tau protein in brain tissue of vascular dementia rats

作　　者：林森[1] 赵颖[1] 王建华[2] 晋光荣[2] 赵连东[1] 

机构地区：[1]江苏省淮安市第二人民医院,江苏淮安223002 [2]东南大学医学院神经生物研究所,江苏南京210009

出　　处：《现代中西医结合杂志》2011年第29期3656-3657,3662,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的研究依达拉奉对血管性痴呆(VD)大鼠脑组织β淀粉样蛋白(Aβ)、Tau蛋白表达的影响。方法通过Morris水迷宫筛选出雄性SD大鼠64只,随机分为正常组、假手术组、对照组、治疗组,术后7,14,28 d分别用Morris水迷宫测试大鼠空间学习记忆能力缺失情况,并取脑组织冰冻切片检测Aβ、Tau蛋白表达情况。结果对照组脑缺血再灌注后1周,神经细胞中Aβ、Tau蛋白的表达阳性细胞数均明显增多(P均<0.01),缺血再灌注4周后更明显(P均<0.001)。治疗组缺血再灌注1周后神经细胞中Aβ、Tau蛋白的表达阳性细胞数均明显少于对照组(P均<0.01),缺血再灌注2周后更明显(P均<0.001)。结论依达拉奉可抑制脑缺血再灌注后脑组织中Aβ、Tau蛋白的表达。Objective It is to study the influence of edaravone on the expressions of beta amyloid（Aβ） and Tau protein in brain tissue of vascular dementia（VD） rats.Methods Sixty-four male SD rats were sieved with Morris water maze and randomly divided into normal group,sham operation group,control group and treatment group.After operation for 7,14 and 28 d,the loss information of space learning memory ability of those rats were tested with Morris water maze,and the frozen sections of brain tissue were taken to detect the expression information of Aβ and Tau protein.Results The increases of the positive expression cell numbers of Aβ and Tau protein in nerve cells of control group were obvious after cerebral ischemia reperfusion for one week（both P〈0.01） and those were more obvious after cerebral ischemia reperfusion for four weeks（both P〈0.001）.The positive expression cell numbers of Aβ and Tau protein in nerve cells of treatment group after ischemia reperfusion for one week were obviously fewer than that in control group（both P〈0.01） and that was more obvious after ischemia reperfusion for two weeks（both P〈0.001）.Conclusion Edaravone can restrain the expressions of Aβ and Tau protein in brain tissue after cerebral ischemia reperfusion.

关 键 词：血管性痴呆 依达拉奉 Β淀粉样蛋白 TAU蛋白 

分 类 号：R-332[医药卫生]