雌激素受体基因Pvu Ⅱ多态性与偏头痛相关性研究  

STUDY OF CORRELATION BETWEEN ESTROGEN RECEPTOR PVUⅡPOLYMORPHISMS AND MIGRAINE

作　　者：霍建新[1] 王萍 敖姝真 高学文 

机构地区：[1]内蒙古医学院研究生学院 [2]内蒙古自治区人民医院神经内科 [3]干部保健科,呼和浩特010010

出　　处：《中国疼痛医学杂志》2011年第9期538-541,共4页Chinese Journal of Pain Medicine

基　　金：内蒙古自治区科技厅科技资助项目(20080502)

摘　　要：目的:探讨雌激素受体基因PvuⅡ多态性与偏头痛基因易感性的关系。方法:选取偏头痛患者41例和健康对照者44例进行病例对照研究,通过聚合酶链反应一限制性片段长度多态性分析(pCR—RFLP)对其雌激素受体基因PvuⅡ基因型进行检测分析。结果:雌激素受体基因PvuⅡ基因型频率在偏头痛患者中′PP′基因型频率为17.1%、′Pp′基因型频率为43.9%、′pp′基因型频率为39%,在健康对照组中各基因型频率分别为13.6%、38.6%、47.7%。偏头痛组与健康对照组基因型频率比较未发现显著性差异(χ2=0.676,P=0.713)。结论:ESR 1基因PvuⅡ多态性可能与偏头痛发病无显著相关性。Objective：To investigate the genetic association between PvuⅡpolymorphisms of estrogen receptor 1（ESR1） and migraine.Methods：A case-control study was performed in 41 migraineurs and 44 controls.For the subjects,ESR1 PvuⅡgenotypes were detected by polymerase chain reaction and restriction fragment length polymorphisms assay.Results：In the migraineurs,PP frequency was 17.1%, Pp frequency was 43.9%and pp frequency was 39%,respectively;in the controls,the corresponding frequency was 13.6%,38.6%and 47.7%,respectively.There was no significant difference in the frequency of ESR1 polymorphisms between the migraineurs and the contros.（χ~2=0.676,P=0.713）. Conclusions：The PvuⅡpolymorphism in ESR1 might have no significant correlation with migraine.

关 键 词：偏头痛 雌激素受体基因1 基因多态性 

分 类 号：R747.2[医药卫生—神经病学与精神病学]