microRNAs在乳腺癌及乳腺癌干细胞中的研究进展  

New progresses of microRNAs researches in breast cancer and breast cancer stem cells

作　　者：李佳[1] 房林[1] 

机构地区：[1]上海市第十人民医院甲状腺乳腺外科,上海200072

出　　处：《国际外科学杂志》2011年第9期632-635,共4页International Journal of Surgery

基　　金：上海市科委基金项目（No.10411964700）

摘　　要：microRNAs在乳腺癌形成和发展中发挥着重要的作用，其可能扮演着原癌基因、抑癌基因、肿瘤转移侵袭、凋亡、耐药凋节者等角色。此外，越来越多的证据表明，miRNAs参与乳腺癌干细胞的增生、自我更新、分化及肿瘤形成。本文分别综述了microRNAs和乳腺癌、乳腺癌干细胞之间的关系及其用于肿瘤治疗的研究进展。microRNAs play a critical role in breast tumorigenesis and progression, in which it might serve as oncogene, tumor suppressor gene, regulators of invasion, apoptosis and therapy resistance. Moreover, there has been a large body of evidences for the involvement of miRNAs in the self-renewal, differentiation and tumor formation of breast cancer stem cells. This review respectively summarizes the relations between microRNAs and breast cancer, breast cancer stern cell as well as the progresses of applying microRNAs to tumor therapy.

关 键 词：MICRORNAS 乳腺癌干细胞 肿瘤治疗 

分 类 号：R737.9[医药卫生—肿瘤]