Biosilica-glass formation using enzymes from sponges [silicatein]： Basic aspects and application in biomedicine [bone reconstitution material and osteoporosis]  

作　　者：Shun-Feng WANG Xiao-Hong WANG Lu GAN Matthias WIENS Heinz C. SCHRODER Werner E, G. MOLLER Werner E. G. MOLLER 

机构地区：[1]National Research Center for Geoanalysis, Chinese Academy of Geological Sciences, 26 Baiwanzhuang Dajie, Beijing 100037, China [2]Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, D-55128 Mainz, Germany

出　　处：《Frontiers of Computer Science》2011年第3期266-281,共16页中国计算机科学前沿（英文版）

摘　　要：In the last 15 years biomineralization, in particular biosilicification （i.e., the formation of biogenic silica, SiO2）, has become an exciting source of inspiration for the development of novel bionic approaches, following ＂Nature as model＂. Among the silica forming organisms there are the sponges that have the unique property to catalyze their silica skeletons by a specific enzyme termed silicatein. In the present review we summarize the present state of knowledge on silicatein-mediated ＂biosilica＂ formation in marine sponges, the involvement of further molecules in silica metabolism and their potential application in biomedicine. Recent advancements in the production of bone replacement material and in the potential use as a component in the treatment of osteoporosis are highlighted.In the last 15 years biomineralization, in particular biosilicification （i.e., the formation of biogenic silica, SiO2）, has become an exciting source of inspiration for the development of novel bionic approaches, following ＂Nature as model＂. Among the silica forming organisms there are the sponges that have the unique property to catalyze their silica skeletons by a specific enzyme termed silicatein. In the present review we summarize the present state of knowledge on silicatein-mediated ＂biosilica＂ formation in marine sponges, the involvement of further molecules in silica metabolism and their potential application in biomedicine. Recent advancements in the production of bone replacement material and in the potential use as a component in the treatment of osteoporosis are highlighted.

关 键 词：BIOMINERALIZATION BIOSILICA medicine biomaterials OSTEOPOROSIS 

分 类 号：TQ174.759[化学工程—陶瓷工业] S858.317.1[化学工程—硅酸盐工业]