哌嗪含磷双取代衍生物的合成及结构表征  

Synthesis and structure characterization of disubstituted piperizine deritives containing phosphorus

作　　者：柳闪星[1] 董保东[1] 葛会玉[1] 吕志丹[1] 廖新成[1] 

机构地区：[1]郑州大学化学系,河南郑州450052

出　　处：《化学研究与应用》2011年第9期1230-1234,共5页Chemical Research and Application

摘　　要：以无水哌嗪为原料,合成了9个1,4-位分别带有磷酰化氨基酸和缩氨基硫脲取代基团的哌嗪衍生物,通过1H NMR、13C NMR、31P NMR、IR、MS对其结构进行表征。并通过ESI-MS研究目标化合物与细胞色素的弱相互作用,初步评价了他们的生物活性。nine target molecules including thiosemicarbazone and N-phosphoryl amino acid groups were synthesized respectively with the raw material of anhydrous piperazine.The structures of nine compounds were confirmed by 1H NMR、13C NMR、31P NMR、IR and MS.And weak interactions between target molecules and cytochrome were studied,their biological activity was discussed.

关 键 词：哌嗪 缩氨基硫脲 弱相互作用 

分 类 号：O626.4[理学—有机化学]