脑低灌注患者检测血浆β淀粉样蛋白1-40和1-42水平的价值  

Evaluation of determination of plasma amyloid beta-protein 1-40 and 1-42 in patients with cerebral hypoperfusion

作　　者：林森[1] 赵连东[1] 周永[1] 赵颖[1] 张新勇[1] 

机构地区：[1]江苏省淮安市第二人民医院,江苏淮安223002

出　　处：《现代中西医结合杂志》2011年第28期3523-3525,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨脑低灌注(CHP)患者血浆中β淀粉样蛋白1-40(Aβ1-40)和Aβ1-42测定的临床价值。方法以ELISA法,检测44例经CT血管成像确定狭窄程度<70%的脑低灌注患者和40例同期对照(HC)者的血浆Aβ1-40和Aβ1-42水平。结果 CHP组血浆Aβ1-40和Aβ1-40/Aβ1-42比值明显高于HC组,而Aβ1-42水平则明显低于HC组。Aβ1-40和Aβ1-42是与血管狭窄相关的独立因素(R2=0.923,P<0.01)。结论脑缺血损伤导致CHP患者血浆Aβ1-40升高和Aβ1-42降低,对其进行检测具有一定的临床诊断价值。Objective It is to measure the level of beta-amyloid protein （1 -40） and （1 -42） （Aβ1 -40, Aβ1-42 ） in patients with cerebral hypoperfusion （CHP） and to explore its clinical value. Methods The plasma levels of Aβ1-40 and Aβ1-42 of 44 cases with a cerebral stenosis degree less than 70% diagnosed by CT angiography and 40 health controls （HC） were measured by ELISA assay. Results The level of plasma Aβ1-40 and ratio of Aβ1 -40/Aβ1-42 in CHP patients were significantly higher than that in HC objectives, while the Aβ1-42 acts the versa （ P 〈 0.01 ）. The plasma Aβ1-40 and Aβ1-42 were independent factors related to vascular stenosis degree （ R2 = 0. 923, P 〈 0.01 ）. Conclusion The increase of plasma Aβ1-40 and decrease of Aβ1-42 can he results from cerebral ischemic insults, which can be detected possessing considerable values for clinical diagnosis.

关 键 词：脑低灌注 β-淀粉样蛋白1—40 β-淀粉样蛋白1—42 

分 类 号：R743[医药卫生—神经病学与精神病学]