不同相对分子质量羟乙基纤维素对甲维盐微胶囊制备的影响  

Effect of Relative Molecular Mass of Hydroxyethyl Cellulose on the Preparation of Emamectin Benzoate Microcapsules

作　　者：李伟[1] 路福绥[1] 翟利利[1] 王祜英[1] 郭雯婷[1] 

机构地区：[1]山东农业大学化学与材料科学学院,泰安271018

出　　处：《应用化学》2011年第10期1108-1113,共6页Chinese Journal of Applied Chemistry

基　　金：山东省自然科学基金资助项目(ZR2009DM032)

摘　　要：采用原位聚合法以三聚氰胺-甲醛树脂为壁材制备了甲维盐微胶囊。探讨了不同黏均相对分子质量羟乙基纤维素作为乳化剂对微胶囊表面形貌、粒径及其分布、包覆率与载药量的影响,对使用不同黏均相对分子质量羟乙基纤维素作为乳化剂制备的微胶囊的释放性能进行了表征。结果表明,以相对分子质量较小的羟乙基纤维素制备的微胶囊外形规则、致密且无黏连现象。随羟乙基纤维素黏均相对分子质量的增加所得微胶囊的平均粒径及粒径分布逐渐增大,包覆率与载药量逐渐减小。释放性能的研究表明,采用相对分子质量较小的羟乙基纤维素制备的微胶囊的释放性能较好。Using different viscosity average relative molecular mass of hydroxyethyl cellulose（HEC） as the emulsifier,microcapsules containing emamectin benzoate were prepared by in-situ polymerization.The factors affecting the surface morphology,the particle size and distribution,the encapsulation efficiency and the drug loading were investigated,and the release properties were determined.The results show that the morphology of the microcapsules made by small relative molecular mass HEC is uniform,dense and the microcapsules have no adhesion phenomenon.With the increase of viscosity average relative molecular mass of HEC,the particle size and the size distribution of microcapsules increase,while the encapsulation efficiency and the drug loading decrease.It is showed that the release performances of the microcapsules which prepared by small relative molecular mass HEC are better.

关 键 词：原位聚合法 黏均相对分子质量 羟乙基纤维素 甲胺基阿维菌素苯甲酸盐 微胶囊 

分 类 号：O633[理学—高分子化学]