CD56与传统神经内分泌标记物在小细胞肺癌中的诊断价值比较  

Comparison of diagnostic values of CD56 and routine neuroendocrine markers

作　　者：黄爱红[1] 玄科 郑瑶[1] 高静[1] 孙凯[1] 陈小丽[1] 王静[1] 

机构地区：[1]桓台县人民医院病理科,256400

出　　处：《滨州医学院学报》2011年第4期274-276,共3页Journal of Binzhou Medical University

摘　　要：目的检测并比较神经细胞黏连分子(NCAM/CD56)与传统神经内分泌标记物嗜铬蛋白(CgA)、突触素(Syn)和神经元特异性烯醇化酶(NSE)在小细胞肺癌(SCLC)诊断中的应用价值。方法采用EnVision免疫组化二步法对41例SCLC存档病例,行CD56、CgA、Syn和NSE检测,以χ2检验分析表达结果。结果小细胞肺癌CD56阳性率为90.24%(37/41),阳性着色位于胞膜,弥漫中～强阳性;CgA阳性率为48.78%(20/41),阳性着色位于胞浆内,多呈弱～中阳性,为灶性表达;Syn阳性率为75.61%(31/41),阳性着色位于胞浆内,多为弥漫弱阳性;NSE阳性率为73.17%(30/41),阳性着色位于胞浆内,部分为弥漫性,部分为灶性表达,多为弱阳性。CD56和Syn、CgA、NSE相比,在SCLC诊断中阳性率差异有统计学意义(P<0.01)。结论 CD56在小细胞肺癌诊断中是一种敏感性更高、特异性更强的免疫标记物,具有更好的诊断应用价值。Objective To compare the diagnosis value of CD56 with routine markers in small cell lung carcimoma.Methods 41 SCLC cases had been collected from the Department of Pathology in People＇s Hospital of Huantai County during the last 3 years.All cases were stained for CD56,CgA,Syn and NSE by EnVision immunohistochemical technique.The data were analyze by Chi-square test.Results 90.24%（37/41）of SCLC cases were positive for CD56.Generally,the stain was diffuse and most cases were moderately to intensely.48.78%（24/41）of the cases showed weak to moderately positive for CgA,the stain was focally stained.The positive percentage for Syn was 75.61%（31/41）.The reaction was diffuse and weak in most cases with a small proportion of them being focally stained.The positive percentage for NSE was 73.17%（30/41）,The reaction was diffuse and weak in most cases.The positive percentages for CD56 and Syn,CgA,NSE were significantly different（P0.01）.Conclusion As auxiliary molecular markers for the diagnosis of SCLC,CD56 showing a positive stain in most SCLC,are confirmed to be reliable neuroendocrine markers.

关 键 词：肿瘤 小细胞肺癌 CD56 嗜铬蛋白 突触素 神经元特异性烯醇化酶 

分 类 号：R734.2[医药卫生—肿瘤]