Ⅲ度羊水污染对新生儿神经系统的影响  

Effect of severe meconium stained amniotic fluid on neonatal nervous system

作　　者：陈娟娟[1] 陈美清[1] 陈光福[1] 

机构地区：[1]广东深圳市第二人民医院儿科,深圳518000

出　　处：《中国实用神经疾病杂志》2011年第17期17-19,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨Ⅲ度羊水污染对新生儿神经系统的影响。方法胎儿宫内窘迫患儿44例,其中Ⅲ度羊水污染20例作为观察组,其余24例患儿为对照组,2组患儿出生后1 min5、min、10 min给予Apgar评分;生后72 h行头颅CT检查;生后第3天、第14天行新生儿神经行为测定(NBNA)。结果观察组1 min Apgar评分、第3天NBNA评分明显低于对照组(t=-2.55,P=0.02;t=-2.31,P=0.03),5 min Apgar评分、10 min Apgar评分、第14天NBNA差异无统计学意义(t=1.45,P=0.16;t=0.04,P=0.97;t=-0.61,P=0.55)。观察组窒息率明显高于对照组(2χ=4.14,P=0.04),头颅CT异常率高于对照组(χ2=4.40,P=0.04),观察组在行为能力方面明显低于对照组(t=-2.31,P=0.03)。结论Ⅲ度羊水污染新生儿窒息明显高于其他胎儿窘迫患儿,脑损伤发生率高,早期护脑干预可减轻脑损伤程度。Objective To explore the effect of severe meconium stained amniotic fluid on neonatal nervous system.Methods Forty-four neonates with fetal distress were divided into severe meconium stained amniotic fluid group as study group（n=20）,and the rest as the control group（n=20）.In neonates of the two groups,1 min,5 min,10 min Apgar score,head CT after birth 72 hours,NBNA scores after birth 3 days and 15 days were analyzed.Results 1 min Apgar score and NBNA after birth 3 days of study group were lower than the control group（t=-2.55,P=0.02;t=-2.31,P=0.03）.5 min Apgar score,10 min Apgar score and NBNA after birth 14 days were different in the two groups（t=1.45,P=0.16;t=0.04,P=0.97;t=-0.61,P=0.55）.Neonatal asphyxia incidence in study group was higher than the control group（χ2=4.14,P=0.04）.The abnormal ratio of head CT in study group was higher than the control group（χ2=4.40,P=0.04）.The score of behavioral ability in study group were lower than the control group（t=-2.31,P=0.03）.Conclusion The ratio of neonatal asphyxia and brain injure in severe meconium stained amniotic fluid were obviously higher than other fetal distress neonates.Early intervention can reduce brain injury.

关 键 词：Ⅲ度羊水污染 胎儿宫内窘迫 新生儿行为神经测定 新生儿窒息 脑损伤 

分 类 号：R722[医药卫生—儿科]