MnSOD基因Val-9Ala多态性与乳腺癌易感性关系的Meta分析  

Manganese Superoxide Dismutase Val-9Ala Polymorphism and Breast Cancer Susceptibility:A Meta-analysis

作　　者：孙国贵[1] 王雅棣[2] 王士杰[3] 郑明民[2] 程云杰[3] 李成林[3] 柴红[4] 

机构地区：[1]河北省唐山市人民医院放化疗科,唐山063000 [2]北京军区总医院放疗科,北京100700 [3]河北医科大学第四医院放疗科,石家庄050011 [4]唐山市工人医院内分泌一科,唐山063000

出　　处：《中国循证医学杂志》2011年第9期1027-1032,共6页Chinese Journal of Evidence-based Medicine

基　　金：国家自然科学基金(30540005);国家人事部高层次留学归国人员资助国人厅发[2005]118号;教育部留学归国人员启动基金教外司留[2008]101号

摘　　要：目的评价锰超氧化物歧化酶(MnSOD)基因Val-9Ala多态性与乳腺癌易感性及经期状态的关系。方法计算机检索Cochrane Library(2010年第1期)、PubMed、CNKI、CBM和万方数据库,按照纳入与排除标准选择相关的病例对照试验,检索时限均为建库至2010年10月。在提取资料和评价质量后,采用RevMan 4.2.10软件进行Meta分析。结果共纳入14个研究,合计17842例患者。Meta分析结果显示,MnSOD基因Val-9Ala多态性与乳腺癌易感性无关[Val/Ala vs.Val/Val:OR=1.04,95%C(I0.93,1.17);Ala/Ala vs.Val/Val:OR=1.12,95%C(I0.95,1.33);Ala/Ala vs.Val/Ala+Val/Val:OR=1.06,95%CI(0.93,1.20);Val/Ala+Ala/Ala vs.Val/Val:OR=1.06,95%CI(0.94,1.10)]。进一步亚组分析结果显示,MnSOD Val/Ala及Ala/Ala基因型会增加绝经前妇女患乳腺癌的风险[Val/Ala+Ala/Ala vs.Val/Val:OR=1.15,95%CI(1.01,1.31)]。结论 MnSOD基因Val-9Ala多态性与乳腺癌易感性无关,但可能增加绝经前妇女患乳腺癌的风险。Objective To explore the association between manganese superoxide dismutase（MnSOD） Val-9Ala polymorphism and breast cancer risk and to investigate the interaction with menopausal status by meta-analysis.Meth-ods Such databases as e Cochrane Libtary（Issue1,2010）,Pubmed,CBM,CNKI and WanFang Data were searched from the date of their establishment to October,2010,and the case-control studies of MnSOD Val-9Ala polymorphism and breast cancer risk were collected according to the inclusion and exclusion criteria.Then the quality of the included trials was assessed and meta-analysis was performed by RevMan 4.2.10 so ware.Results A total of 14 studies involv-ing 17842 patients were included.The results of meta-analyses showed no significant relation between MnSOD Val-9Ala polymorphism and the breast cancer susceptibility（Val/Ala vs.Val/Val： OR=1.04,95%CI 0.93 to 1.17;Ala/Ala vs.Val/ Val： OR=1.12,95%CI 0.95 to 1.33;Ala/Ala vs.Val/Ala＋Val/Val： OR=1.06,95%CI 0.93 to 1.20;Val/Ala＋ Ala/Ala vs.Val/ Val： OR=1.06,95%CI 0.94 to 1.10）.However,in the subgroup analysis,the breast cancer risk significantly increased for premenopausal women（Val/Ala＋Ala/Ala vs.Val/Val： OR=1.15,95%CI 1.01 to1.31）.Conclusion This meta-analysis suggests that the MnSOD Val-9Ala polymorphism is not signi cantly associated with the breast cancer susceptibility,but it may increase the risk of breast cancer in the presence of menopausal state.

关 键 词：锰超氧化物歧化酶 乳腺癌 基因多态性 肿瘤易感性 META分析 

分 类 号：R737.9[医药卫生—肿瘤]