复方苦参注射液对晚期非小细胞肺癌患者生活质量影响  

Impact of Fufang Kushen Injection on Quality of Life in Patients with Advanced Non-small Cell Lung Cancer

作　　者：王洪娟[1] 王建华[1] 杨俊泉[1] 赵凯[1] 李义慧[1] 张爱静[1] 

机构地区：[1]河北省唐山市人民医院放化疗科,河北唐山063000

出　　处：《实用预防医学》2011年第9期1787-1788,共2页Practical Preventive Medicine

摘　　要：目的探讨复方苦参注射液对晚期非小细胞肺癌患者生活质量影响。方法将唐山市人民医院2010年1月-2011年1月应用复方苦参注射液治疗的136例晚期非小细胞肺癌患者的临床资料进行回顾性分析,136例患者采用复方苦参注射液20 ml加入生理盐水250 ml中静脉滴注,每天1次,连用2周,每3周重复,共计3~9个治疗周期,根据WHO标准评价患者近期疗效,采用肺癌生活质量量表对患者生活质量进行评价。结果①136例患者均可评价疗效,其中CR 0例,PR 6例（4.4%）,SD 27例（19.9%）,PD 103例（75.7%）。客观缓解率4.4%,疾病控制率24.3%。②治疗前后症状、功能状态和整体生活质量评分的均值改变（P〈0.05）。结论复方苦参注射液可以改善晚期非小细胞肺癌患者症状,提高生活质量。Objective To explore the effect of Fufang Kushen injection on quality of life in patients with advanced non-small cell lung cancer.Methods The clinical data of 136 patients with advanced non-small cell lung cancer patients who received the therapy of Fufang Kushen injection in the People＇s Hospital of Tangshan City from January 2010 to January 2011 were retrospectively analyzed.136 patients were treated with Fufang Kushen injection in 20 ml normal and saline 250ml intravenous infusion,once every day,for 2 successive weeks,repeated every 3 weeks,a total of 3~9 treatment cycles.According to the WHO criteria,the questionnaires about quality of life were used to evaluate the short-term efficacy in the patients.Results The responses of all the patients could be evaluated.There were 0 patient with CR,6（4.4%） patients with PR,27（19.9%） patients with SD,and 103（75.7%） patients with PD.The objective response rate was 4.4%,and the disease control rate was 24.3%.The symptoms after treatment,functional status and mean score of quality of life were changed（P0.05）.Conclusions Fufang Kushen injection can release the symptoms of patients and improve the quality of life.

关 键 词：非小细胞肺癌 复方苦参注射液 FACT-L 生活质量 

分 类 号：R734.2[医药卫生—肿瘤]