TFF与消化系统肿瘤关系的研究进展  

Research on Relations between Trefoil Factor and Digestive Tumors

作　　者：冯丽英[1] 马丽[1] 秦玉彩[1] 

机构地区：[1]河北医科大学第二医院消化科,石家庄050000

出　　处：《临床误诊误治》2011年第9期82-85,共4页Clinical Misdiagnosis & Mistherapy

基　　金：河北省科技厅科技攻关计划项目(05276101D-49)

摘　　要：TFF是一族主要表达于胃肠道黏膜的小分子多肽,包括乳腺癌相关肽、解痉多肽和肠三叶因子,其主要功能是维持黏膜的完整性和促进损伤黏膜的修复。近年研究发现TFF与消化系统肿瘤的发生、发展有关,同时对细胞的增殖和凋亡有一定的影响,因此,进一步研究TFF在消化系肿瘤中的作用机制,将为消化系肿瘤的诊断与治疗开辟新的途径。Trefoil factor（TFF） peptides are a family of small molecular regulatory protein which is mainly expressed in gastrointestinal mucus membrane,including TFFl（PS2）,TFF2（SP）and TFF3（ITF）.Its main function is to keep the integrity of mucous membranes and promote the repair of epithelial damage.Recent studies have found that trefoil factor family has connection with the occurrence and development of digestive tumors.At the same time it has a certain impact on cell proliferation and apoptosis.Therefore further study on mechanism of trefoil factor family in gastrointestal tumor will provide new approaches for the diagnosis and treatment of gastrointestal cancer.

关 键 词：三叶因子 肽类 消化系统肿瘤 细胞增殖 细胞凋亡 

分 类 号：R735[医药卫生—肿瘤]