盐酸文拉法辛缓释胶囊和氟西汀治疗抑郁症的对照研究  

作　　者：徐丽珍[1] 林泽涯[1] 

机构地区：[1]泉州市第三医院,福建泉州362000

出　　处：《中外医疗》2011年第26期5-5,7,共2页China & Foreign Medical Treatment

摘　　要：目的观察文拉法辛治疗抑郁症的疗效和安全性。方法患者随机分为文拉法辛组[(175±20)mg/d,n=48]和氟西汀组(20mg/d,n=50),疗效采用HAMD17项评分,不良反应采用TESS和监测血压。疗程均为6周。结果文拉法辛组痊愈率39.6%,有效率68.8%;氟西汀组痊愈率30.0%,有效率5%,2组比较差异无统计学意义。但文拉法辛组在HAMD量表减分值方面,第1、2、4周均更明显。2组在不良反应上无统计学差异。结论文拉法辛治疗抑郁症起效较快、疗效肯定、安全性较好。Objective To explore the efficacy and safety of Venlafaxine and fluoxetine in the treatment of patients with depression.Methods 98 patients met CCMD-3 criteria for depressive episode were randomly divided into research group[（175±20）mg/d,m=48]took orally Venlafaxine and control group（20mg/d,n=50） did Fluoxetine for 6 weeks.Efficacies were assessed with the Hamiton Depression Sale（HAMD）and adverse reactions with the Treatment Emergent Sympton Scale（TESS） and blood pressure monitoring.Results Total effective rates were respectively 68.8% in the research and 58% in the control group,the total efficacies of both groups were equivalence（P0.05）.The HAMD scores lowered did more significantly in the research than in the control grorp at the end of the 1st,2nd and 3rd week.Adverse reactions of both groups were equivalence.Conclusion Venlafaxine has therapeutic equivalence to fluoxetine,but takes effects quicker and has higher safety in the treatment ot depression.

关 键 词：文拉法辛 氟西汀 安全性 疗效 抑郁症 

分 类 号：R749[医药卫生—神经病学与精神病学]