血清胰蛋白酶原-2对胰腺癌的诊断价值  

Diagnostic value of serum trypsinogen-2 in patients with pancreatic cancer

作　　者：崔婷婷[1] 郭汉斌[1] 李浩然[1] 马丽[1] 李冰[1] 杜囚鹏[1] 曹建彪[1] 

机构地区：[1]中国人民解放军北京军区总医院全军肝病治疗中心,北京市100700

出　　处：《世界华人消化杂志》2011年第22期2386-2390,共5页World Chinese Journal of Digestology

摘　　要：目的:研究血清胰蛋白酶原-2与胰腺癌的相关性.方法:选取中国人民解放军北京军区总医院内、外科诊断为胰腺癌未经治疗的患者23例;发病<12h、未经生长抑素治疗的胰腺炎患者30例,对照组随机选取体检中心健康体检者35人.入组者留取血清标本,采用ELISA法定量检测血清胰蛋白酶原-2的含量.结果:胰腺癌组患者血清胰蛋白酶原-2中位数为13.8μg/L,四分位间距为2.3-60.7μg/L,胰腺炎组中位数为82.7μg/L,四分位间距为21.45-201.5μg/L,对照组中位数为0.8μg/L,四分位间距为0.6-1.2μg/L.三组间两两比较差异均有统计学意义(P<0.01),其中胰腺炎组血清胰蛋白酶原最高,胰腺癌组次之,均明显高于正常对照组.以44.05μg/L为临界值,此时血清胰蛋白酶原-2鉴别胰腺癌与胰腺炎的敏感度和特异度分别为63.3%和73.9%,ROC曲线下的面积为0.725.以1.85μg/L为临界值,鉴别诊断胰腺癌与健康人的敏感度为91.4%,特异度为95.7%,ROC曲线下的面积为0.989.结论:血清胰蛋白酶原-2与胰腺癌相关,其含量检测作为一种非侵入性筛选试验,为临床早期胰腺癌筛查提供了手段.AIM： To evaluate the significance of serum trypsinogen-2 in the detection of pancreatic cancer.METHODS： Fresh serum samples were collected from 23 patients with pancreatic cancer, 30 patients with pancreatitis who received no prior treatment with somatostatin, and 35 normal controis. Serum levels of trypsinogen-2 were measured by ELISA.RESULTS： The median level of serum trypsinogen-2 was significantly higher in patients with pancreatitis and those with pancreatic cancer than in normal controls （82.7 μg/L, 13.8μg/L vs 0.8 μg/L both P 〈 0.01）. The sensitivity and specificity of detection of serum trypsinogen-2 for differentiation between patients with pancreatic cancer and normal controls were 91.4% and 95.7%, respectively, and the area under the ROCcurve was 0.989. The sensitivity and specificity for differentiation between pancreatic cancer and pancreatitis were 63.3% and 73.9%, respectively, and the area under the ROC curve was 0.725.CONCLUSION： Detection of serum trypsinogen-2 can be used to screen early pancreatic cancer.

关 键 词：胰腺癌 胰腺炎 血清胰蛋白酶原-2 诊断 

分 类 号：R576[医药卫生—消化系统]