溃疡性结肠炎患者凝血及抗凝标志物的变化及与血小板的相关性研究  

Plasma levels of fibrinopeptide A,prothrombin fragment 1+2,antithrombin Ⅲ and their association with platelet count in patients with ulcerative colitis

作　　者：秦月花[1] 潘颖颖[1] 朱美丽[1] 

机构地区：[1]绍兴市人民医院消化内科,浙江绍兴312000

出　　处：《中国预防医学杂志》2011年第9期755-757,共3页Chinese Preventive Medicine

基　　金：绍兴市卫生局科研项目(2009A33008)

摘　　要：目的探讨溃疡性结肠炎(UC)患者凝血标志物血浆纤维蛋白肽A(FPA)、凝血酶原片段1+2(F1+2)、抗凝标志物抗凝血酶-Ⅲ(AT-Ⅲ)的变化及与血小板的相关性。方法采用ELISA法检测40例活动期UC患者、20例缓解期UC患者及20例健康对照者的FPA、F1+2、AT-Ⅲ水平。结果血浆FPA、F1+2水平活动期UC患者高于缓解期UC及对照组,缓解期UC患者高于对照组,AT-Ⅲ水平活动期UC低于缓解期UC及对照组,缓解期UC患者低于对照组,各组比较差异有统计学意义(P<0.01);活动期UC患者随着疾病严重度加重血浆FPA、F1+2水平逐渐升高(P<0.05),血浆AT-Ⅲ水平逐渐下降,差异有统计学意义(P<0.01);随着病变范围扩大,血浆FPA、F1+2水平升高(P<0.05),血浆AT-Ⅲ水平下降(P<0.01)。结论 UC患者处于明显的血栓前状态,FPA、F1+2、AT-Ⅲ水平的变化与疾病活动性、疾病严重程度、病变累及范围及血小板数量有关。Objective To study the plasma levels of fibrinopeptide A（FPA）,prothrombin fragment 1＋2（F1＋2）,antithrombin Ⅲ（AT-Ⅲ）and their association with platelet count in patients with ulcerative colitis（UC）.Methods We randomly selected 40 active UC patients,20 remissive UC patients and 20 healthy individuals for the study.The plasma levels of FPA,F1＋2 and AT-III were measured by the methods of enzyme linked immunosorbant assays（ELISA） for all participants,respectively.Results The concentrations of FPA and F1＋2 were significantly different in the three groups of participants（P0.05）,which were the highest in patients with active UC,followed by those in patients with remissive UC and healthy individuals.The concentration of AT-Ⅲ was the lowest in patients with active UC,which was followed by that in patients with remissive UC and healthy controls（P0.01）.The increases of FPA,F1＋2 concentrations and the decrease of AT-Ⅲ concentration were associated with UC severity and the lesion areas in active UC patients（P0.01）.There were significantly positive correlation between platelet count and the concentrations of FPA and F1＋2 in UC patients.A negative correlation was confirmed between the concentration of AT-Ⅲ and FPA or F1＋2 or platelet count（P0.05）.Conclusion The levels of FPA,F1＋2 and AT-Ⅲ were correlated with disease activity and severity in patients with UC.There was an obvious prothrombotic state in active UC patients.

关 键 词：溃疡性结肠炎 纤维蛋白肽A 凝血酶原片段1+2 抗凝血酶-Ⅲ 

分 类 号：R574.62[医药卫生—消化系统]