共聚焦显微内镜对胃癌及癌前期病变的实时病理诊断价值  

The real time pathological diagnosis value of confocal laser endomicroscopy in gastric cancer and precancerous disease

作　　者：吴巍[1] 李晨[1] 郭滟[2] 蔚青[2] 朱延波[3] 吴云林[1] 袁耀宗[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院消化科,200025 [2]上海交通大学医学院附属瑞金医院病理科,200025 [3]上海同济大学附属第十人民医院病理科

出　　处：《中华消化杂志》2011年第8期509-512,共4页Chinese Journal of Digestion

摘　　要：目的了解共聚焦显微内镜（CLE）实时诊断胃癌及癌前病变的准确性及与最终病理诊断间的一致性。方法2010年1月至2011年3月间，在上海交通大学医学院附属瑞金医院消化科门诊及住院患者中筛选临床疑及胃癌或癌前病变者进行CLE检查，检查中使用荧光素钠作为荧光剂。采用四级诊断标准对CLE图像进行实时诊断，并据此对病灶行导向活检。对CLE确诊或高度疑为恶性的病变行外科手术治疗。总结常规内镜、CLE及最终病理诊断情况。结果总计160例患者纳入研究，其中1例因荧光素钠过敏而未能完成检查，其余159例患者完成CLE检查。总被检病灶194个，病灶数共计1、2、3个者分别有130、23、6例。CLE总体诊断准确率93．3％（181／194）。CLE对恶性病变的诊断敏感度为93．6％，特异度为99．3％。CLE与最终病理诊断间的一致性良好（Kappa值=0．876）。荧光素钠相关严重不良反应发生率仅o．6％（1／160）。结论CLE检查可精确判定胃癌及癌前病变，与组织病理学一致性良好，对胃癌早期诊断、避免漏诊或误诊具重要意义。Objective To investigate the accuracy and the consistency with pathological diagnosis of confocal laser endomicroscopy （CLE） in real-time diagnosis of gastric malignancy and precancerous diseases. Methods From January 2010 to March 2011, the out-patients and hospitalized patients of suspected gastric malignancy or precancerous diseases in Shanghai Ruijin Hospital were screened and undergone confoeal laser endomicroscopy. Fluorescein sodium was used as fluorescent agent in the examination. A four-tiered diagnostic system was applied in the real time diagnosis with CLE images, and targeted biopsy was performed accordingly. Surgery was performed in CLE diagnosed or highly malignancy suspected patients. The diagnosis of common endoscopy, CLE and pathology was reviewed. Results A total of 160 patients were enrolled in this study, of those one patient withdrew because of fluorescin allergy and the rest 159 patients completed the CLE examination. A total of 194 lesions were inspected, among them, 130 cases each with one lesion, 23 cases each with two lesions and 6 cases each with three lesions. Overall accuracy rate of CLE was 93.3% （181/194）. And the sensitivity and specificity of CLE in gastric malignancy diagnosis was 93.6% and 99.3% respectively. Ideal correlation was identified between confocal laser endomicroscopy and final pathology results （Kappa = 0. 876）. The incidence of marked fluorescin-related adverse events was only 0.6% （1/160）. Conclusions CLE is consistent with histopathology and is helpful to make accurate diagnosis of gastric malignancy and precancerous diseases. It is important in early diagnosis of gastric malignancy and helps to avoid misdiagnosis and missed diagnosis.

关 键 词：胃肿瘤 癌前状态 内窥镜检查 显微镜检查 共焦 

分 类 号：R735.2[医药卫生—肿瘤]