新辅助化疗对乳腺癌ER、PR、P-gp、GST-π表达的影响  

Effects of Neoadjuvant Chemotherapy on Expression of ER,PR,P-gp and GST-π in Breast Cancer

作　　者：王志[1] 黄建军[2] 

机构地区：[1]安顺市人民医院普外科,贵州安顺561000 [2]贵阳医学院附院乳腺外科,贵州贵阳550004

出　　处：《贵阳医学院学报》2011年第4期344-346,350,共4页Journal of Guiyang Medical College

基　　金：贵州省卫生厅基金项目:黔卫发[2007]119号

摘　　要：目的:探讨新辅助化疗对乳腺癌ER、PR、P-gp、GST-π表达的影响。方法:采用免疫组织化学法检测91例乳腺癌患者在新辅助化疗前后乳腺癌灶组织ER、PR、P-gp、GST-π的表达。结果:新辅助化疗前后ER有9例由阳性转为阴性,6例由阴性转阳性,P>0.05;PR有9例由阳性转为阴性,有11例由阴性转为阳性,P>0.05;P-gp在化疗前后的阳性表达率分别为41.75%和64.83%,差异有统计意义(P<0.05);GST-π在化疗前后的阳性表达率分别为49.45%和54.94%,差异无统计意义(P>0.05)。结论:新辅助化疗对乳腺癌组织ER、PR表达状态无显著影响;新辅助化疗后P-gp表达显著升高,对乳腺癌新辅助化疗疗效有一定预测价值。Objective：To study the effects of neoadjuvant chemotherapy on expression of ER,PR,P-glycoprotein（P-gp） and Glutathione S-transferase Pi（GST-π） in breast cancer.Methods：Immunohistochemistry method was adopted to measure the expressions of ER,PR,P-gp and GST-π in 100 patients with breast cancer before and after neoadjuvant chemotherapy.Results：The status of ER and PR changed in 15 and 20 cases respectively;and there was no significant difference before and after neoadjuvant chemotherapy.The positive rate of P-gp before and after chemotherapy were 41.75% and 64.83% respectively,and the difference was statistically significant（P0.05）.The positive rates of GST-π before and after chemotherapy were 49.45% and 54.94% respectively,and no significant difference was found between them（P0.05）.Conclusions：Neoadjuvant chemotherapy has no significant influence on status of ER and PR.The expression of P-gp increased significantly after neoadiuvant chemotherapy.It suggests that P-gp could be used for prediction of therapeutic efficacy of neoadiuvant chemotherapy.

关 键 词：乳腺肿瘤 化学疗法 辅助 多药耐药相关蛋白类 谷胱甘肽转移酶 

分 类 号：R737.9[医药卫生—肿瘤]