测定血清降钙素原浓度指导抗生素治疗急性脑出血发热效果分析  

The Value of Serum Procalcitonin in Treatment of Pyrexia after Acute Cerebral Hemorrhage

作　　者：蔡云余[1] 胡永启[1] 易兴阳[1] 

机构地区：[1]浙江省瑞安市人民医院急诊科,浙江瑞安325200

出　　处：《中国现代医生》2011年第28期29-30,91,共3页China Modern Doctor

摘　　要：目的探讨通过测定血清中降钙素原(Procalcitonin,PCT)浓度指导临床抗生素治疗急性脑出血发热的疗效。方法我院2009～2011年共收治急性脑出血并发发热患者100例,患者随机分为两组,分别为常规组和PCT组,每组50例,所有患者在治疗急性脑出血的基础上,常规组按照抗生素使用指南进行治疗,PCT组根据血清中降钙素原浓度指导抗生素治疗。分别对两组患者的抗生素费用、抗生素使用率、病死率、美国国立卫生院卒中量表(NIHSS)评分以及临床有效率进行分析比较。结果常规组和PCT组抗生素费用和抗生素的使用率分别为(4418.6±703.5)、94%和(2071.2±433.4)、62%,两组相比具有显著性统计学意义(P<0.05)。与常规组比较,PCT组患者治疗后30d病死率、NIHSS评分以及临床有效率均无显著性差异(P>0.05)。结论通过测定血清中PCT浓度指导临床抗生素治疗急性脑出血发热可降低患者抗生素的使用率以及抗生素的费用,对防止患者产生耐药性以及降低患者的经济负担具有重要的意义。Objective To assay the value of serum procalcitonin （ PCT ） in treatment of pyrexia after Acute cerebral hemorrhage. Methods All 100 patients with Acute cerebral hemorrhage from 2009 to 2011 were divided randomly into standard group （ 50 cases ） and PCT group （ 50 cases ）. Patients in standard group were treated with antibiotics according to the attending physicians. Control group was treated with antibiotics according to serum PCT levels. The costs of antibiotics, rate of antibiotics using, mortality, NIHSS and clinical efficacy on the 30th day were assayed. Results The costs of antibiotics and rate of antibiotics using were （ 4418.6 ± 703.5 ）, 94% and （ 2071.2 ± 433.4 ）,62% in standard group and PCT group. It is significant between standard group and PCT group （ P 〈 0.05 ）. Mortality, NIHSS and clinical efficacy were similar in two groups （P 〉 0.05 ）. Conclusion PCT guidance reduced antibiotics use and costs of antibiotics in treatment of pyrexia after Acute cerebral hemorrhage

关 键 词：降钙素原 抗生素 急性脑出血 发热 

分 类 号：R743.34[医药卫生—神经病学与精神病学]