血清甲胎蛋白、β2-微球蛋白和癌胚抗原在原发性肝癌鉴别诊断中的价值  

Diagnostic Value in Distinguishing Primary Liver Cancer by Combined Detection of Alpha Fetoprotein,Carcinoembryonic Antigen and β2-Microglobulin

作　　者：应晓剑[1] 符鸿俊[1] 黄美君[1] 

机构地区：[1]台州医院路桥院区,浙江台州318050

出　　处：《中国现代医生》2011年第28期85-86,共2页China Modern Doctor

摘　　要：目的探讨血清甲胎蛋白、β2-微球蛋白和癌胚抗原在原发性肝癌中的诊断价值,进一步提高原发性肝癌诊断的准确率。方法采用放射免疫法测定正常健康人、肝癌、肝硬化、肝血管瘤患者血清中甲胎蛋白、β2-微球蛋白和癌胚抗原的含量。结果单项甲胎蛋白、β2-微球蛋白、癌胚抗原的血清水平,原发性肝癌组与肝硬化、肝血管瘤组、健康对照组比较差异有统计学意义(P<0.05);甲胎蛋白、β2-微球蛋白、癌胚抗原联合阳性率显著高于单项甲胎蛋白阳性率;甲胎蛋白对原发性肝癌诊断的特异性及敏感性均高于其他两项肿瘤标记物。结论血清甲胎蛋白、β2-微球蛋白和癌胚抗原是独立的肿瘤标记物,联合应用更有助于原发性肝癌与肝硬化、肝血管瘤等其他肝脏疾病的鉴别诊断。Objective To explore the diagnostic value in distinguishing primary liver cancer by combined detection of alpha fetoprotein, carcinoembryonic antigen and β 2-microglobulin, and further to improve the diagnosis accuracy for primary liver cancer. Methods To test the levels of alpha fetoprotein, carcinoembryonic antigen and β 2-microglobulin by radioimmunoassay in the patients with primary liver cancer, liver cirrhosis, liver hemangioma and the controls. Results The leves of alpha fetoprotein, carcinoembryonic antigen or β 2-microglobulin were significant different among the primary hepatic carcinoma, liver cirrhosis, liver hemangioma and the normal healthy people （P 〈 0.05 ）.When combined the alpha fetoprotein, carcinoembryonic antigen and β 2- microglobulin, the accuracy was improved.The specificity and sensitivity of alpha fetoprotein were both higher than the other two tumor markers in the diagnosis of primary liver cancer. Conclusion Alpha fetoprotein, carcinoembryonic antigen and β2-microglobulin are the independent tumor markers in diagnosis of primary hepatic carcinoma.Combining those three markers is helpful to distinguish the primary liver cancer from liver cirrhosis and liver hemangioma.

关 键 词：甲胎蛋白 Β2-微球蛋白 癌胚抗原 原发性肝癌 

分 类 号：R735.7[医药卫生—肿瘤]