转化生长因子β1与内皮素转换酶－1b基因多态性和颈动脉粥样硬化易感性的关联研究  

Association between polymorphisms of transforming growth factor β1 gene and endothelin converting enzyme-lb gene and susceptibility of carotid atherosclerosis

作　　者：冯骏[1] 肖新莉[2] 刘哲[3] 秦皓[1] 刘丽华[1] 张敏[1] 张波[1] 刘亚民[1] 

机构地区：[1]西安交通大学医学院第一附属医院神经内科脑血管病区,西安710061 [2]西安交通大学医学院人体解剖与组织胚胎学系,西安710061 [3]西安电力中心医院外科,西安710032

出　　处：《中华神经医学杂志》2011年第9期879-882,共4页Chinese Journal of Neuromedicine

基　　金：基金项目：陕西省科技攻关项目（2006K13-G7）

摘　　要：目的探讨转化生长因子β1基因与内皮素转换酶-1b基因多态性和颈动脉粥样硬化易感性的关联情况。方法选择西安交通大学医学院第一附属医院神经内科自2006年1月至2010年12月收治的231例脑梗死住院患者为患者组，同期社区健康自愿参与研究者231例为对照组，运用PCR及单核苷酸多态性技术分析2组成员转化生长因子β1基因与内皮素转换酶-1b基因多态性分型．比较2组间基因和基因型差异。结果患者组和对照组转化生长因子β1基因的rs51695112位点基因和基因型差异有统计学意义（x^2=6．120、6．890，P=0．045、O．033），G等位基因和G／G基因型为颈动脉粥样硬化易感性的高危因素（OR=1．320、1．410）；患者组和对照组内皮素转换酶-1b基因rs32570233位点基因和基因型差异有统计学意义萨6．320、7．180，P=0．041、O．022），A等位基因和A／A基因型为颈动脉粥样硬化易感性的高危因素（OR=1．470、1．530）。结论转化生长因子β1基因、内皮素转换酶-1b基因多态性与颈动脉粥样硬化相关联。Objective To study the relationship between polymorphisms of transforming growth factor β1 gene and endothelin converting enzyme-lb gene and susceptibility of carotid atherosclerosis. Methods Two hundred and thirty-one patients with carotid atherosclerosis, admitted to and received treatment in our hospital from January 2006 to December 2010, and 231 healthy volunteers were chosen in our study. The polymorphisms of transforming growth factor β1 gene and endothelin converting enzyme-lb gene in these 2 groups were detected with PCR and single nucleotide polymorphism; the differences of these gene and genotype between the 2 groups were compared by statistical analysis. Results The gene and genotype of transforming growth factor β1 gene at rs51695112 locus were significantly different between patient group and control group （X^2=6.120, 6.890; P=0.045, 0.033, respectively）; the G allele and G/G genotype were risk factors of carotid atherosclerosis susceptibility （OR=1.320, 1.410, respectively）. The gene and genotype of endothelin converting enzyme-lb gene at rs32570233 locus were significantly different between the patient group and the control group （x^2=6.320, 7.180; P=0.041, 0.022）; the A allele and A/A genotype were the risk factors of carotid atherosclerosis susceptibility （OR=1.470, 1.530, respectively）. Conclusion There is an association between polymorphisms of transforming growth factor β 1 gene and endothelin converting enzyme-lb gene and carotid atherosclerosis.

关 键 词：动脉粥样硬化 颈动脉 转化生长因子Β1 内皮素转换酶-1b 多态性 单核苷酸 

分 类 号：R743.3[医药卫生—神经病学与精神病学]