氨基酸介导的TOR信号传导通路研究进展  

Recent Advances on TOR Signaling Transduction Pathways Medicated by Amino Acids

作　　者：邓会玲[1] 刘国华[1] 刘宁[1] 

机构地区：[1]中国农业科学院饲料研究所,北京100081

出　　处：《动物营养学报》2011年第4期529-535,共7页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家肉鸡产业技术体系建设专项(nycytx-42-G4-03)

摘　　要：TOR(target of rapam ycin)是一种进化上十分保守的丝氨酸(Ser)/苏氨酸(Thr)蛋白激酶,可以感知营养状况、能量、生长因子等信号,进而调节细胞的生长、增殖和凋亡等生理进程。本文综述了TOR的上、下游信号传导通路及各种氨基酸对TOR信号传导通路的影响,为探讨氨基酸调控蛋白质合成的作用机制及建立精确的营养供给技术提供了开创性思路。The target of rapamycin（TOR）,an evolutionarily conservative Ser/Thr protein kinase,can perceive signals such as nutritional status,energy and growth factors to regulate cell growth,proliferation and apoptosis and other physiological processes.The upstream and downstream signaling pathways of TOR and the effects of various amino acids on signaling transduction pathways were reviewed in this paper,which provides a theoretical basis and innovative ideas for discussing amino acid regulation of protein synthesis and the establishment of the precise mechanism of nutrient supply technology.

关 键 词：氨基酸 TOR 信号传导通路 

分 类 号：Q55[生物学—生物化学]