表观遗传因素在RNA剪接过程中的作用  

Role of Epigenetic Factors in RNA Splicing

作　　者：陈伟[1,2] 罗辽复[2] 

机构地区：[1]河北联合大学理学院基因组学与计算生物学中心,唐山063000 [2]内蒙古大学物理科学与技术学院,呼和浩特010021

出　　处：《中国生物化学与分子生物学报》2011年第9期791-796,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.90403010);河北联合大学博士科研启动基金(No.10101115)资助~~

摘　　要：RNA剪接是真核生物基因表达过程中的重要环节,增加了蛋白质的多样性和基因表达的可调节性.日益增多的研究表明,RNA剪接并不是独立的生物过程.RNAⅡ型聚合酶(RNApolymerase-Ⅱ,RNA PolⅡ)、核小体定位和组蛋白修饰等因素都与RNA剪接过程密切相关.阐明RNA PolⅡ、核小体定位和组蛋白修饰等因素在RNA剪接过程中的作用,将为剪接位点的准确识别和剪接调控机制的研究提供新思路.本文综述了RNA PolⅡ、核小体定位和组蛋白修饰等因素对RNA剪接的影响以及它们在RNA剪接过程中的调控作用.RNA splicing is an important process involved in gene transcriptional regulation.RNA splicing not only increases the diversity of proteins,but also enlarges the scope of gene expressional regulation.Recent studies indicate that RNA splicing is coupled with transcription and can be regulated by RNA polymerase-Ⅱ,nucleosome positioning and histone modification.Illuminating roles of epigenetic factors in the process of RNA splicing will facilitate the identification of splice sites and provide novel insights into mechanisms of splicing regulation.In this article,molecular functions of these factors on RNA splicing are reviewed in term of the links between RNA polymerase-Ⅱ,nucleosome positioning,histone modification and RNA splicing,respectively.

关 键 词：RNAPolⅡ 核小体定位 组蛋白修饰 RNA剪接 

分 类 号：Q61[生物学—生物物理学]