野菊花总黄酮对酒精性脂肪肝大鼠的防治作用  被引量:15

The protective and therapeutic effects of total flavonoids of Chrysanthemumindicu on alcoholic steatohepatitis

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作  者:王保伟[1] 李俊[1] 程文明[1] 孙静[1] 王雯[1] 赵冰封[1] 

机构地区:[1]安徽医科大学药学院,合肥230032

出  处:《安徽医科大学学报》2011年第10期1022-1025,共4页Acta Universitatis Medicinalis Anhui

摘  要:目的探讨野菊花总黄酮(TFC)对大鼠酒精性脂肪性肝的防治作用及部分机制。方法以酒精联合脂肪乳剂灌胃,每天2次,连续6周,制备大鼠酒精性脂肪性肝模型。TFC(84、168、336 mg/kg)组和凯西莱组同时灌服相应药物。于实验第6周末采血,检测血清丙氨酸氨基转移酶(ALT)、天门冬氨基转移酶(AST)、总胆固醇(TC)、甘油三酯(TG)、乙醇脱氢酶(ADH)、肿瘤坏死因子-α(TNF-α)及肝组织超氧化物岐化酶(SOD)、丙二醛(MDA),并做肝脏病理学检查。结果 TFC(168、336 mg/kg)组能明显降低酒精性脂肪性肝大鼠血清AST、ALT、TC、TG、ADH、TNF-α水平,降低肝脏中MDA含量,增强SOD活性;同时病理组织学显示TFC能明显改善酒精性脂肪性肝炎大鼠的肝细胞脂肪变性。结论 TFC对大鼠酒精性脂肪性肝炎具有较好的防治作用。其作用机制可能与调节脂质代谢,减轻脂质过氧化损伤、提高血液中ADH含量,抑制TNF-α过表达有关。Objective To explore the protective and therapeutic effects of total flavonoids of Chrysanthemumindicu(TFC) on alcoholic steatohepatitis and its mechanisms.Methods The rats of the model group were fed with ethanol and fat emulsion twice a day for 6 weeks.At the same time,the rats of TFC group and tiopronin group were administrated with relative dose of medicine.By the end of the 6th week,all rats were sacrificed.The serum ALT,AST,TG,TC,ADH,TNF-α and hepatic SOD,MDA were measured respectively.Hepatic histopathology was observed by microscope.Results Serum levels of ALT,AST,TG,TC,ADH,TNF-α decreased significantly in administration of TFC(168,336 mg/kg),hepatic levels of MDA markedly reduced,meanwhile the activity of SOD enhanced.The histopathological analysis suggested that TFC could significantly ameliorate fatty degeneration of hepatocytes.Conclusion TFC has positively protective and therapeutic effects on alcoholic steatohepatitis.The pharmacological mechanisms are probably related with adapting blood lipid component,decreasing lipid peroxidation enhancing the levels of ADH in serum,inhibit TNF-α expression.

关 键 词:脂肪肝 酒精性 脂质过氧化 野菊花总黄酮 

分 类 号:R575.5[医药卫生—消化系统] R282.71[医药卫生—内科学]

 

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