复制型HBV转基因小鼠的建立与应用  

Establishment and use of HBV-replication transgenic mice

作　　者：孔祥平 刘光泽 易学瑞 

机构地区：[1]解放军458医院全军肝病中心、全军转基因动物重点实验室,广州510600

出　　处：《解放军医学杂志》2011年第9期954-958,共5页Medical Journal of Chinese People's Liberation Army

基　　金：“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项“十一五”课题(2008ZX10002-011)

摘　　要：尽管有了有效的疫苗,但乙肝病毒(HBV)感染依然是全球性公共卫生问题,在我国形势尤为严峻。由于HBV的自然宿主仅限于人和黑猩猩,现有的模型都有不同的缺陷,因此关于其生物学及治疗方法研究的诸多问题依然没有解决。复制型HBV转基因小鼠模型的建立,极大地提高了我们对HBV生活史、免疫生物学和肝脏病变的免疫发病机制的认识。本文简要介绍国际上由Francis V.Chisari实验室和国内由本实验室建立的复制型HBV转基因小鼠,以及利用该模型开展抗病毒药物和乙肝发病机制的研究工作。Despite the existence of a preventive vaccine,hepatitis B virus（HBV） infection is still a major worldwide health problem,especially in China.As HBV naturally Despite of the existence of a preventive vaccine,hepatitis B virus（HBV） infection is still a major worldwide healthy problem,especially in China.As HBV naturally infects only human and chimpanzees,many issues pertaining to the biology and the therapeutic of HBV infection remain unresolved due to the limitation of the establishment of a HBV model.However,the establishment of HBV-replication transgenic mice has greatly improved our understanding of life cycle,immunobiology and pathogensis of HBV.The establishment of HBV transgenic mice and its use in assessing the antiviral potential of pharmacological agents and HBV immunopathogenesis are herewith briefly described in the present paper.

关 键 词：小鼠 转基因 肝炎病毒 乙型 抗病毒药 模型 动物 

分 类 号：R576.1[医药卫生—消化系统]