E-cad、EGFR、MMP9与肺癌转移的关系  

Study on Relationship between Expression of E-cad,EGFR and MMP9 and Metastasission in NSCLC

作　　者：杜心佳[1] 刘希光[1] 

机构地区：[1]青岛大学医学院附属医院,山东青岛266003

出　　处：《现代生物医学进展》2011年第18期3480-3484,共5页Progress in Modern Biomedicine

摘　　要：目的:探讨原发性非小细胞肺癌(NSCLC)组织中E-钙粘蛋白(E-cadherin,E-cad)、表皮生长因子受体(Epidermal Growth FactorReceptor,EGFR)和基质金属蛋白酶9(matrix metalloproteinase-9,MMP9)的表达与术后复发及转移的关系。方法:选择临床IB期非小细胞肺癌患者的手术切除标本,其中36例于36个月之内发生复发或转移,30例术后无病生存期超过36个月。采用免疫组织化学方法检测组织中E-cad、EGFR、MMP9的表达情况。结果:36例早转移IB期非小细胞肺癌术后患者的手术标本中,E-cad的异常表达率、EGFR及MMP9的阳性表达率,均明显高于30例非早转移IB期非小细胞肺癌术后患者(P<0.05),且在早转移IB期NSCLC中,三者的表达与病理分级、肿瘤大小有关(P<0.05),与病理类型,肿瘤是否浸润胸膜无关(P>0.05)。结论:对早期肺癌术后病人,检测E-cad、EGFR、MMP9的表达,对判断其恶性程度,提示肿瘤的复发及转移倾向大小,决定术后治疗方案有重要意义。Objective： To study clinical relationship between the expression of E-cadherin（E-cad）, epidermal growth factor receptor （EGFR）, malrix metalloproteinase-9（MMP9）and postoperative recurrence and distant metastasis in patients with non-small lung cancer （NSCLC）. Method： lmmuno- histochemical method （SP） was used to detect the expression of the E-cad, EGFR, MMP9 in 36 IB stage NSCLC tissues which had transferred within 3 year after operation and 30 IB stage NSCLC tissues which hadn＇t transferred within 3 year after operation. Result： The positive expression rates of EGFR,MMP9 and the abnormal expression rates of E-cad in the early transferred IB stage NSCLC were higher than those in the non-early transferred IB stage NSCLC （P〈0.05）. Significant difference of the expression level of the E-cad, EGFR, MMP9 in early transferred IB stage NSCLC was found between different pathological grades and different tumor size （P〈0.05）. There was no significant correlation between E-cad, EGFR or MMP9 expression and pathological type or whether infiltrating pleural （P〉0.05）. Conclusion： Examination of expression levels of the E-cad, EGFR and MMP9 was of significance in malignant potential ,prognosis and treatment of early NSCLC.

关 键 词：上皮型钙粘附蛋白 表皮生长因子受体 金属基质酶9 早转移非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]