钙黏附素和β-连接素与宫颈上皮内瘤变进展的关系  

Expression and the Significance of E-cadherin and β-catenin in Cervical Intraepithelial Neoplasia

作　　者：张娟娟[1] 陈永平[2] 张天峰[1] 吴秀霞[1] 

机构地区：[1]深圳市第五人民医院,广东深圳518001 [2]妇科微创治疗中心,广东深圳518001

出　　处：《现代生物医学进展》2011年第18期3491-3493,共3页Progress in Modern Biomedicine

摘　　要：目的:观察钙黏附素(E-cadherin)和β-连接素(β-catenin)在不同级别宫颈上皮内瘤变组织中的表达,探讨其与宫颈上皮内瘤变进展的关系。方法:采用免疫组化法检测51例宫颈组织病理存档石蜡包埋组织钙黏附素(E-cadherin)和β-连接素(β-catenin)的表达,阳性信号采用图像分析仪进行定量分析。结果:E-cadherin在柱状上皮移位组及CIN I组、CIN II组、CIN III组中的平均光密度值(AOD)分别为:0.0866±0.0392、0.073±0.0122、0.0467±0.0056、0.0396±0.0097;β-catenin在柱状上皮移位组及CIN I组、CIN II组、CIN III组中的平均光密度值(AOD)分别为:0.1101±0.0116、0.1016±0.0108、0.0711±0.0062、0.0515±0.0091。随着CIN病变的升级,钙黏附素和β-连接素的表达均呈下降趋势,二者的平均光密度值(AOD)正相关(r=2.546,P=0.018<0.05)。结论:钙黏附素、β-连接素与宫颈上皮内瘤变的进展相关,在估计CIN的预后中有一定意义。Objective： To investigate the expression and the significance of E-cadherin and β -catenin in cervical intraepithelial neoplasia. To analysis whether a relationship between expression of E-cadherin and β -catenin and progression of cervical intraepithelial neoplasia. Methods： E-cadherin and β -catenin expressions in 51 cases of CIN and columnar ectopy was detected by Immunohistochemistry method and automatic image analysis technique. Results： The AOD values of E-cadherin in the columnar ectopy group,CIN I group, CIN II group and CIN III group are separately： 0.0866± 0.0392,0.073± 0.0122,0.0467± 0.0056,0.0396± 0.0097. The AOD values of 13 -catenin in the columnar ectopy group,CIN I group,ClN II group and CIN III group are separately： 0.1101 ± 0.0116,0.1016± 0.0108, 0.0711± 0.0062,0.0515± 0.0091.The expressions of E-cadherin and β -catenin in cervical intraepithelial neoplasias are positive correlation notablely （r-2.546,P〈0.05）. Conclusions： The results indicate that decreased E-cadherin and β -catenin expression might be related to the progression of cervical intraepithelial neoplasia, the two indicator might be a useful tool to evaluate the prognosis of CIN.

关 键 词：钙黏附素 Β-连接素 宫颈上皮内瘤变 宫颈肿瘤 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]