肾细胞癌淋巴结转移预测指标的Logistic回归分析  

Prediction of Lymph Node Metastasis in RenalCellCarcinoma by Binary Logistic Regression

作　　者：舒博[1] 杜新香[1] 陈鹏[1] 毕兴[1] 申钧[1] 

机构地区：[1]新疆医科大学附属肿瘤医院泌尿外科,新疆乌鲁木齐830011

出　　处：《现代生物医学进展》2011年第18期3527-3530,共4页Progress in Modern Biomedicine

摘　　要：目的:研究肾细胞癌淋巴结转移的危险因素,并建立Logistic回归模型。方法:2002年2月～2010年10月我院手术治疗的肾细胞癌163例,对其临床病理资料进行单因素和多因素的Logistic回归分析。结果:淋巴结转移的发生率为20.9%(34/163)。单因素分析显示:肿瘤大小、临床分期、Fuhrman核分级和贫血与肾细胞癌淋巴结转移的风险有关(P<0.05);多因素分析显示:肿瘤大小、临床分期和Fuhrman核分级是RCC淋巴结转移独立的风险因素。结论:肾细胞癌淋巴结转移的风险与肿瘤大小、临床分期和Fuhrman核分级有关,Logistic回归模型对于判断预后、指导术后治疗及随访方案的制订具有重要作用。Objective： To study the risk factors of lymph node metastasis of renal cell Carcinoma （ RCC ） and to set up a Logistic regression model. Methods： The clinical data of 163 patients with renal cell carcinoma who underwent radical nephrectomy from 2002 to 2010 in Affiliated Tumor Hospital of Xinjiang Medicial University, were analyzed by univariate and binary Logistic regression. Results： The incidence of lymph node metastasis was 20.9%. Univariate logistic analysis revealed that the tumor size, clinical stage, Fuhrman nu- clear grade and anemia were all correlated with lymph node metastasis of RCC （P 〈 0.05 ）. Binary logistic analysis found that the tumor size（OR-1.828,P〈0.01 ）, clinical stage（OR-6.296, P〈0.01 ）and the Fuhrman nuclear grade（OR-0.377, P〈0.05 ）were the independent risk factors responsible for lymph node metastasis of RCC. Conclusion： The risk factors for lymph node metastasis in patients with renal cell carcinoma were correlated with the tumor size, clinical stage and Fuhrman nuclear grade, The Logistic regression model may be use- ful for prognosis and making the postoperative treatment and follow-up program for patients with RCC.

关 键 词：肾肿瘤 淋巴结转移 危险因素 回归分析 

分 类 号：R737.11[医药卫生—肿瘤]