磁共振测量嗅球容积在阿尔茨海默病早期诊断中的价值  

The early diagnositic value of olfactory bulb volume measurement with MRI to Alzheimer' disease

作　　者：俱西驰[1] 屈秋民[1] 张明[2] 郭晨光[1] 吴谦[3] 杨华[1] 郭峰[1] 罗国刚[1] 金晨旺[2] 

机构地区：[1]西安交通大学医学院第一附属医院神经内科,陕西西安710061 [2]西安交通大学医学院第一附属医院影像科,陕西西安710061 [3]西安交通大学医学院公共卫生学系,陕西西安710061

出　　处：《南京医科大学学报（自然科学版）》2011年第9期1337-1340,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:研究阿尔茨海默病(Alzheimer’disease,AD)嗅球容积变化,探讨嗅球容积测定用于AD早期诊断的可能性。方法:轻度AD患者及正常对照各31例,磁共振(magnetic resonance imaging,MRI)测量海马体积及嗅球容积,简易精神状态量表(mini-mental status examination,MMSE)评价整体认知功能,分析海马体积、嗅球容积与MMSE分值的关系。结果:轻度AD组嗅球容积(115.39±5.76)mm3和经颅腔容积校正的嗅球容积(82.59±7.85)mm3均明显小于正常对照组的(126.96±9.79)mm3及(94.53±9.88)mm3(P<0.01)。AD组嗅球容积与MMSE评分呈正相关(r=0.49,P<0.05)。轻度AD组海马体积(2.07±0.30)mm3明显小于正常对照组(2.37±0.35)mm3(P<0.01)。AD组海马体积与MMSE评分呈正相关(r=0.44,P<0.05)。AD组嗅球容积与海马体积呈正相关(r=0.69,P<0.01)。MRI测量嗅球容积诊断轻度AD的特异性和敏感性分别为0.65和0.78,测量海马体积诊断轻度AD的特异性和敏感性分别为0.91和0.74。结论:轻度AD患者嗅球容积明显缩小,并与认知功能减退正相关,但MRI测量嗅球容积诊断轻度AD的准确性不如测量海马体积。Objective： To study the early diagnositic value of olfactory bulb volume measurement with MRI to Alzheimer＇ disease.Methods： Total of 31 patients with Alzheimer＇ disease（AD） and 31 healthy elderly control was measured about olfactory bulb volume and hippocampal volume with magnetic resonance imaging（MRI）.Their congnition function were measured by mini-mental status examination（MMSE）,relationship between MMSE and olfactory bulb volume or hippocampal volume were analyzed.Results： AD group was significantly atrophy compared with the controls in olfactory bulb volume and hippocampal volume（P 0.01）.The correlation in AD group was found between hippocampal volume and MMSE scores（r = 0.44,P 0.05）,and between olfactory bulb volume and MMSE scores（r = 0.49,P 0.05）.A significant correlation in AD group was found between olfactory bulb volume and hippocampal volume（r = 0.69,P 0.01）.The specificity and sensitivity of olfactory bulb volume measurement with MRI to Alzheimer＇ disease are respectively 0.65 and 0.78.The specificity and sensitivity of hippocampal volume measurement with MRI to Alzheimer＇disease are respectively 0.91 and 0.74.Conclusion： Olfactory bulb volume in patients with AD was significantly smaller,and has significant correlation with congnition function reduction,but the diagnostic accuracy of olfactory bulb volume measurement with MRI to AD is no better than that of hippocampal volume.

关 键 词：磁共振 海马体积 嗅球容积 阿尔茨海默病 

分 类 号：R749.1[医药卫生—神经病学与精神病学]