心力衰竭治疗的毒性评估：对Q—T间期影响的研究  

Evaluation of Toxicity for Heart Failure Therapeutics=Studying Effects on the QT Interval

作　　者：童鸿 

出　　处：《心电学杂志》2011年第5期439-443,共5页Journal of Electrocardiology(China)

摘　　要：前言 医学上最可怕的并发症之一是由药物诱发的心律失常导致的猝死。因此，在药物注册审批前，要求协同努力去确定致心律失常的潜在特性。监测Q-T间期延长是这样的一种方法√山力衰竭患者，Introduction One of the most feared complications in medicine is sudden death caused by drug-induced proarrhythmia. Accordingly, concerted efforts have been made to define a drug＇s proarrhythmic potential before regulatory approval. Monitoring for QT prolongation is one such method. Patients with heart failure represent a particularly high-risk population for torsade de pointes because of structural and electric remodeling that impair repolarization reserve.~,~~~,b^（^P）~~

关 键 词：心力衰竭 毒性评估 Q-T间期延长 致心律失常 治疗 药物诱发 药物注册 并发症 

分 类 号：R541.6[医药卫生—心血管疾病]