原发性血小板增多症血栓形成的相关因素分析  

Correlating factors for thrombosis in patients with essential thrombocythemia

作　　者：刘凌[1] 庞缨[1] 叶絮[1] 周旭红[1] 冯莹[1] 

机构地区：[1]广州医学院第二附属医院血液内科,510260

出　　处：《实用医学杂志》2011年第19期3508-3510,共3页The Journal of Practical Medicine

基　　金：广州市卫生局科研立项项目(编号:2009-YB-160);广州医学院第二附属医院科研立项项目(编号:303005639)

摘　　要：目的:研究原发性血小板增多症血栓形成与JAK2-V617F突变及各临床相关因素的关系。方法:纳入原发性血小板增多症患者64例,继发性血小板增多症患者50例,分析其血栓发生率和JAK2-V617F突变率及相关临床因素的关系。结果:原发性血小板增多症患者血栓发生率高于继发性血小板增多症(P<0.01)。原发性血小板增多症血栓组JAK2-V617F突变率高于非血栓组(P<0.05);血栓组白细胞数、vWF:Ag、年龄高于非血栓组(P<0.05),AT-Ⅲ、PC活性低于非血栓组(P<0.05);血栓组血红蛋白量、血小板数、PS值与非血栓组无明显差异(P>0.05)。结论:原发性血小板增多症患者血栓形成率高,与JAK2-V617F突变、高龄、高白细胞、高vWF:Ag及低AT-Ⅲ、低PC相关。Objective To study the relationship between JAK2-V617F mutation,clinical parameters and thrombosis in patients with essential thrombocythemia （ET）.Methods Sixty-four patients with ET （ET group）,50 patients with secondary thrombocythemia （ST group） were included in this study.Correlation between the incidence of thrombosis and JAK2-V617F mutation rate,clinical parameters were analyzed.Results The incidence of thrombosis in ET group was higher than that in ST group（P 0.01）.JAK2-V617F mutation rate was higher in patients with thrombosis than that in patients without thrombosis in ET group （P 0.05）.The white blood cell count,vWF：Ag,and age in patients with thrombosis were significantly higher than those in patients without thrombosis in ET group（P 0.05）,while antithrombin Ⅲ （AT-Ⅲ） level,protein C activity were lower （P 0.05）.The hemoglobin level,platelet count,protein S （PS） level were not significantly different between the two groups （P 0.05）.Conclusions The incidence of thrombosis in patients with ET was high,and was correlated with JAK2-V617F mutation,old age,high white blood cell count,high vWF：Ag levels,and low AT-Ⅲ and PC levels.

关 键 词：血小板增多 血栓形成 JAK2-V617F 基因突变 

分 类 号：R55[医药卫生—血液循环系统疾病]