^(13)C-美沙西汀呼气试验在慢性肝病分期中的作用  

Diagnostic Value of the ^(13)C Methacetin Breath Test in Various Stages of Chronic Liver Disease

作　　者：刘迎迎[1] 陈红莲[1] 

机构地区：[1]漯河医学高等专科学校医疗系,462002

出　　处：《中国医疗前沿》2011年第14期3-4,共2页China Healthcare Innovation

摘　　要：目的通过在选定患者中进行13C-美沙西汀呼气试验(13C-MBT),进而评估13C-MBT在慢性肝病患者肝纤维化与硬化分期中的作用。方法选取40例慢性肝病患者进行13C-MBT,通过收集呼气样本,采用非色散同位素选择性红外光谱仪(IRIS)测定13CO2/12CO2同位素比值。以敏感性、特异性、阳性预测值(PPV)、阴性预测值(NPV)和UCB分析确定13C-MBT在慢性肝病分期中的诊断价值。结果 MBT评估肝纤维化、肝硬化、Child-Pugh A级、B级和C级的敏感性与阳性预测值分别为66%和55%,90%和90%,68%和43%,42%和41%,50%和76%。肝纤维化的UCB为0.60,肝硬化UCB为0.94。结论13C-MBT对于肝纤维化无预测价值,但可准确评估进展期肝硬化。Objective To determine the diagnostic value of the 13C Methacetin Breath Test in various stages of chronic liver disease by 13C-methacetin breath test（13C-MBT） in the choosed patients.Methods Forty patients of Chronic Liver Disease were recruited.13C-MBT was performed.Breath samples were obtained.The 13CO2/12CO2 isotope ratio in the breath samples was analyzed by nondispersive isotope-selective infrared spectrometry.Diagnostic accuracy of the breath test was determined by sensitivity,specificity,positive predictive value,negative predictive value,and area under the curve analysis.Results The sensitivity and positive predictive value for liver fibrosis,cirrhosis（all stages）,Child-Pugh A,Child-Pugh B,and Child-Pugh C were 66% and 55%,90% and 90%,68% and 43%,42% and 41%,and 50% and 76%,respectively.Area under curve values for fibrosis was 0.60,whilst that for cirrhosis（all stages） was 0.94.Conclusion The 13C-methacetin breath test has a poor predictive value for liver fibrosis but accurately determines advanced cirrhosis.

关 键 词：13C-美沙西汀呼气试验 慢性肝病 肝纤维化 肝硬化 

分 类 号：R575[医药卫生—消化系统]