肝硬化出血患者血小板4项参数及凝血因子的动态变化  

The dynamic changes of 4 platelet parameters and coagulation factor in bleeding patients with liver cirrhosis

作　　者：洪炜[1] 杨宁[1] 何江英[1] 曲芬[1] 毛远丽[1] 

机构地区：[1]解放军第302医院临床检验医学中心,北京100039

出　　处：《中国卫生检验杂志》2011年第9期2250-2251,2253,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨肝硬化出血患者血小板参数与凝血因子动态变化的临床意义。方法:对54例肝硬化出血患者出血前第13、7、d的凝血酶原时间(PT)、血小板计数(PLT)、血小板压积(PCT)、平均血小板体积(MPV)、平均血小板分布宽度(PDW)、大血小板比率(P-LCR)进行动态检测,同时将患者初入院的相应指标作为对照组,并进行统计学比较。结果:PLT与对照组比较,肝硬化出血患者出血前1 d3、d、7 d具有明显下降的趋势,PDW、P-LCR、PT则明显升高。PCT、MPV无明显差异。结论:肝硬化患者由于血小板数量减少、血小板功能缺陷及凝血功能障碍易合并消化道出血,动态监测其综合测定值有助于作为肝硬化患者出血倾向的预警,指导早期防治。Objective： To investigate the clinical significance of dynamic changes of the platelet parameters and coagulation factors in bleeding patients with liver cirrhosis.Methods： Fifty four cases of bleeding patients with liver cirrhosis were observed.The prothrombin time（PT）,platelet count（PLT）,platelet hematocrit（PCT）,mean platelet volume（MPV）,mean platelet distribution width（PDW） and large platelet ratio（P-LCR） were detected in 1 d,3 d,7 d before bleeding and observed the change tenderly,while the same indexes at early admission in patients as control group were compared.Results： Compared with control group,PLT significantly decreased and PDW,P-LCR,PT significantly increased in 1 d,3 d,7 d before bleeding in patients with liver cirrhosis,but PCT,MPV had no significant difference between before bleeding and after bleeding.Conclusion： As the platelet count decrease in patients with cirrhosis,defective platelet function and blood coagulation disorder are easily combined with gastrointestinal bleeding,dynamic monitoring of the PLT,PDW,P-LCR and PT in patients with cirrhosis can help make early warning and prevention guidance.

关 键 词：肝硬化 出血 血小板参数 凝血因子 

分 类 号：R575.2[医药卫生—消化系统]