加巴喷丁治疗中重度晚期癌症患者内脏痛的临床评价  

Clinical evaluation of gabapentin on the treatment of moderate and severe visceral pain in advanced cancer patients

作　　者：辛立[1] 张颜波[2] 李美艺 牛敬忠[2] 谢娜[2] 

机构地区：[1]泰山医学院附属医院肿瘤科,山东泰安271000 [2]泰山医学院附属医院神经内科,山东泰安271000 [3]山东省慢性病医院神经内科,山东泰安271000

出　　处：《泰山医学院学报》2011年第5期324-326,共3页Journal of Taishan Medical College

基　　金：山东省高等学校科技计划(J10LF14)

摘　　要：目的观察加巴喷丁对晚期癌症伴中重度疼痛患者内脏痛的镇痛效果与不良反应。方法 50例患者随机分为两组,试验组(25例)应用加巴喷丁,开始第一天睡前服300 mg,以后每天增加300 mg,连续5天,上述剂量分3次服用;对照组(25例)盐酸吗啡片1-2片,毎6小时1次,连续5天。评价指标为疼痛缓解率、不良反应。结果加巴喷丁总的缓解率为68%;对中、重度缓解率分别为83.33%和25.57%;中、重度缓解率比较,有显著性差异(P<0.01)。加巴喷丁组对照组比较,镇痛效果无显著性差异(P>0.05)。加巴喷丁组不良反应主要为头晕,与对照组比较,无显著性差异(P>0.05)。结论加巴喷丁对晚期癌症伴中重度疼痛患者内脏痛具有镇痛作用,对中度疼痛效果良好,不良反应少。Objective： To explore analgesic effects and adverse reactions of gabapentin on moderate and severe visceral pain in advanced cancer patients.Method： Fifty patients were randomly divided into 2 groups,in which the experimental group（25 patients） received gabapentin,300mg at bedtime the first day,then increased by 300mg each day in 5 days in a row,and the above dose was token in 3 times;the control group（25 patients） received 1 to 2 morphine hydrochloride tablets,once every 6 hours and consecutively in 5 days.Evaluation indexes were pain relief rate and adverse reactions.Results： The overall relief rate of gabapentin was 68%;the relief rate for severe and moderate was respectively 25.57% and 83.33%;significant difference was found between moderate and severe（P0.01）.Analgesic effect showed no significant difference between the experimental group and the control group（P0.05）.The main adverse reaction in gabapentin group was dizziness,compared with the control group,and no significant difference was seen（P0.05）.Conclusion： Gabapentin has analgesic effect on moderate and severe visceral pain in advanced cancer patients,better effect on moderate pain and less adverse reaction.

关 键 词：加巴喷丁 内脏痛 癌症 缓解率 

分 类 号：R730.5[医药卫生—肿瘤]