脑出血后迟发性脑水肿血浆sFas和sFasL水平分析  

Plasma level of sFas and sFasL in acute cerebral hemorrhage with delayed cerebral edema

作　　者：王兆平[1] 王文静[1] 王前友 潘健[2] 孙一兵 

机构地区：[1]安徽医科大学附属省立医院神经内科,安徽合肥230001 [2]安徽医科大学附属省立医院检验科,安徽合肥230001 [3]安徽医科大学附属省立医院影像科,安徽合肥230001

出　　处：《中风与神经疾病杂志》2011年第9期809-812,共4页Journal of Apoplexy and Nervous Diseases

基　　金：安徽省卫生厅课题(2010C032)

摘　　要：目的探讨可溶性Fas(sFas)和可溶性Fas配体(sFasL)的变化与急性脑出血(ACH)后迟发性脑水肿的关系。方法 ACH后迟发性脑水肿患者12例,其中男性9例;随机选取同期ACH无迟发性脑水肿组12例,其中男性8例;同期年龄和性别相匹配的12例健康体检合格者作为对照组,其中男性8例。采用酶联免疫吸附法(ELISA)法测定血浆sFas和sFasL浓度,比较各组之间sFas和sFasL浓度差异。结果 ACH后迟发性脑水肿组14d血浆sFas和sFasL水平明显高于ACH无迟发性脑水肿组和对照组(P﹤0.01),ACH后迟发性脑水肿组较ACH无迟发性脑水肿组于发病7d后血浆sFas和sFasL水平下降速度缓慢,血浆sFasL水平稍有上升。结论 sFas和sFasL可能参与脑出血后迟发性脑水肿的形成,动态性检测血浆sFas和sFasL水平,可对于发现潜在的ACH后迟发性脑水肿具有一定的意义。Objective To investigate the relationship between the changes of the plasma levels of soluble Fas(sFas),soluble Fas-ligand(sFasL) and delayed cerebral edema following acute cerebral hemorrhage(ACH).Methods Our study included 12 cases of ACH with delayed cerebral edema patients(male 9) and 12 cases of ACH without delayed cerebral edema(male 8) and 12 cases of the age and sex matched healthy subjects(male 8).The plasma levels of sFas and sFasL were measured by enzyme-linked immunosorbent assay(ELISA) method in these groups and the difference in the levels of sFas and sFasL were compared among each groups.Results The levels of serum sFas and sFasL at 14d after onset in ACH with delayed cerebral edema group were significantly higher than that of the ACH without delayed cerebral edema and control groups(P<0.01) and that in ACH with delayed cerebral edema group was slow rate of decline at 7d after onset.The levels of serum sFasL in ACH with delayed cerebral edema group were increased slightly 7d after onset.Conclusion The sFas and sFasL probably take roles in the process of ACH with delayed cerebral edema and their dynamicity may be a certain significance for identify potential ACH with delayed cerebral edema.

关 键 词：脑出血 SFAS SFASL 迟发性脑水肿 细胞凋亡 

分 类 号：R743.34[医药卫生—神经病学与精神病学]