水通道蛋白1在卵巢癌组织中的表达  

Expression of aquaporin 1 in human ovarian carcinoma tissue

作　　者：王艳丽[1] 朱继红[1] 高永梅[1] 张利群[1] 

机构地区：[1]吉林大学第一医院妇产科,吉林长春130021

出　　处：《中国实验诊断学》2011年第9期1480-1482,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的明确水通道蛋白1(Aquaporin,AQP1)在卵巢浆液性肿瘤组织中的表达并探讨与腹水形成的关系。方法应用免疫组织化学技术检测AQP1在66例卵巢浆液性肿瘤组织和10例正常卵巢组织中的表达。结果①卵巢浆液性交界性肿瘤阳性表达率(5例,62.5%)和卵巢浆液性恶性肿瘤阳性表达率(38例,82.6%)高于正常卵巢组织(2例,20%)(P<0.05)。②在卵巢恶性浆液性肿瘤中AQP1的表达,中分化癌、低分化癌与高分化癌表达,差异无显著性(P>0.05);在临床分期上,Ⅰ期、Ⅱ期和Ⅲ-Ⅳ期表达,差异无显著性(P>0.05)。③卵巢浆液性癌有腹水的高于无腹水的(P<0.05)。结论 AQP1可在卵巢癌组织表达,并且可能与卵巢癌腹水的发生有关。Objective To determine the expression of Aquaporin1（AQP1） in ovarian serous tumor and investigate it was relationship with ascites.Methods A total of 66 frozen ovarian tissues of serous tumor and 10 of normal ovarian tissues were examined for the expression of AQP1 by immunohistochemistry.Results ①It was statistically difference between either ovarian serous borderline tumor（5 case,62.5%） or ovarian serous malignant（38 case,82.6%） and normal ovarian tissue（2 case,20%）（P〈0.05）.②Expression of AQP1 in ovarian serous malignant carcinoma has no relationship with it was histological grade（P〉0.05） and clinical stage（P〉0.05）.③Expression of AQP1 was statistically different between the cases of with（26 case,72.2%）and without ascites（4 case,40%）（P〈0.05）.Conclusion Expression of AQP1 in ovarian carcinoma was positive and might have relationship with ascites in ovarian carcinoma.

关 键 词：水通道蛋白1 卵巢浆液性肿瘤 腹水 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]