COX-2、MMP-9在甲状腺癌中的表达及临床意义  

Clinical Significances of Expression of COX-2,MMP-9 in Thyroid Carcinoma

作　　者：华特波[1] 孟宪瑛[1] 张强[1] 任江[1] 刘嘉[1] 

机构地区：[1]吉林大学白求恩第一医院甲状腺外科,吉林长春130021

出　　处：《中国实验诊断学》2011年第9期1491-1493,共3页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省卫生厅科研课题(编号2008Z017)

摘　　要：目的探讨COX-2、MMP-9在甲状腺癌中的表达及其临床意义。方法免疫组化法检测COX-2、MMP-9在甲状腺癌、甲状腺瘤、结节性甲状腺肿及及正常甲状腺组织的表达情况,并对临床病理特征及淋巴结转移进行对比分析。结果 COX-2、MMP-9在甲状腺癌中的表达明显高于甲状腺良性病变,与年龄、肿瘤大小、肿瘤包膜性、临床分期有密切关系(P<0.05),COX-2与淋巴结转移有显著相关(P<0.05)。COX-2、MMP-9均与性别无明显关系(P>0.05)。结论 COX-2和MMP-9可作为甲状腺癌重要的恶性生物学指标,检测COX-2和MMP-9有助于术前诊断甲状腺癌及判定淋巴结转移、肿瘤浸润情况,使患者得到及时有效治疗。Objective To discuss the expression and clinical significance of COX-2,MMP-9 in thyroid carcinoma.Methods Expression of COX-2,MMP-9 are detected in thyroid carcinoma、thyroid adenoma、nodular goiter and normal thyroid tissue by immunohistochemical method.Results Expression of COX-2,MMP-9 in thyroid carcinoma groups are obviously higher than that of thyroid benigh tumors,which presents an intimate relationship with age,tumor size,membrane integrality and clinical stage（P〈0.05）,the expression of COX-2 is correlated with lymph node metastasis（P〈0.05）,but negatively correlated with patient gender（P〉0.05）.Conclusion Detection of COX-2 and MMP-9 can act as an preoperative diagnosis method for thyroid cancer and an evaluation of lymph node metastasis and tumor infiltration as an malignant biological indicator,which provide an effective treatment for patients.

关 键 词：环氧化酶-2 基质金属蛋白酶-9 甲状腺癌 免疫组织化学 

分 类 号：R736.1[医药卫生—肿瘤]