绿豆蛋白对染铅大鼠肾功能及SOD、MDA的影响  

The Effect of Greenbeans Protein on Kidney Function and Serum SOD,MDA in Rats by Lead

作　　者：杨毅[1] 徐锦龙[1] 徐强[1] 姜建民[1] 

机构地区：[1]浙江省中药研究所,浙江杭州310053

出　　处：《中华中医药学刊》2011年第10期2280-2281,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省经贸委中药现代化专项资助项目(2009)

摘　　要：目的:观察绿豆提取物蛋白A与蛋白B对染铅大鼠肾功能及抗氧化活性的影响。方法:建立染铅大鼠模型,连续给药30天,测定血肌酐、血尿素氮及血尿酸、血清SOD及MDA。结果:绿豆蛋白B(30g/kg)对能降低染铅大鼠血肌酐、血尿素氮及血尿酸含量(P<0.05),绿豆蛋白A(15g/kg)、绿豆蛋白B(30g/kg)均能显著性降低染铅大鼠的血清MDA含量,绿豆蛋白B(30g/kg)显著性提高染铅大鼠的血清SOD活力(P<0.05)。结论:绿豆蛋白对染铅大鼠具有一定的改善肾功能及提高抗氧化的作用。Objective：To observe the Greenbeans protein A and B on kidney function and antioxidant activity in rats by lead.Methods：SCr,BUN and UA,serum SOD and MDA were tested after the lead-exposed rats were continuous administration of 30d.RESULTS： The Greenbeans protein B（30g/kg） could reduce lead exposure in rats on SCr,BUN and UA（P0.05）,then Greenbeans protein A（15g/kg） and B（30g/kg） both could significantly reduce serum MDA,and Greenbeans protein B（30g/kg） was significantly increased serum SOD activity（P0.05）.Conclusion：The Greenbeans protein in rats by lead had some improvements to improve kidney function and antioxidant effect.

关 键 词：绿豆蛋白 染铅大鼠 肾功能 抗氧化 

分 类 号：R285.5[医药卫生—中药学]