调强适形放疗联合化疗及射频热疗对局部晚期非小细胞肺癌的疗效研究  

Clinical Research on Intensity Modulated Radiation Therapy(IMRT) Combined with Concurrent Chemotherapy and RF Hyperthermia in ⅢB Non-Small-Cell Lung Cancer(NSCLC)

作　　者：王汉华[1] 戴真煜[1] 袁翠莲[1] 

机构地区：[1]江苏省盐城市第三人民医院,224005

出　　处：《实用癌症杂志》2011年第5期493-495,共3页The Practical Journal of Cancer

摘　　要：目的研究调强适形放疗联合化疗及射频热疗,治疗局部晚期非小细胞肺癌的疗效及不良反应。方法将84例NSCLC患者随机分成两组(治疗组与对照组),每组42例。治疗组采用调强适形放疗,常规分割2 Gy/次,每周5次,总剂量60 Gy/30次;化疗采用NP方案,与放疗同步进行,并同时行射频热疗,每周2次。对照组单纯采用NP方案化疗。结果治疗组放射性肺炎发生率为2.4%,放射性食管炎发生率为26.2%,Ⅰ～Ⅱ度白细胞下降发生率为47.6%,Ⅲ度白细胞下降发生率为14.3%,中位生存期为17.6个月,1、2、3年生存率分别为63.5%、38.5%、29.5%,而对照组Ⅰ～Ⅱ度、Ⅲ度白细胞下降发生率分别为42.9%、11.9%,中位生存期为11.3个月,1、2、3年生存率分别为41.0%1、2.4%4、.0%。结论调强适形放疗联合同期化疗及射频热疗治疗局部晚期非小细胞肺癌,可明显提高患者局部控制率及1、2、3生存率,且不良反应小。Objective To analyze the effectiveness and negative effects of intensity modulated radiation therapy combined with concurrent chemotherapy and RF hyperthermia in ⅢB non-small-cell lung cancer.Methods 84 patients with Non-small-cell Lung Cancer（NSCLC） were randomly divided into the treatment group and the control group.In the treatment group patients were given intensity modulated radiation therapy,with a total dose of 60 Gy,2 Gy/fraction,5 fractions/week,combined with NP（NVB＋DDP） chemotherapy and RF Hyperthermia.In the control group,patients received NP chemotherapy only.Results Radiation-induced pneumonitis,radiation induced esophagitis,Ⅰ-Ⅱ°and Ⅲ° leukocytopenia were 2.4%,26.2%,47.6% and 14.3%;The median survival rate was 11.3 months,and 1,2,3 year overall survival were 63.5%,38.5% and 29.5%,respectively.In the control group,the rate of Ⅰ-Ⅱ°and Ⅲ° leukocytopenia was 42.9% and 11.9%.The median survival rate was 11.3 months,and the 1,2 and 3 year overall survival rate were 41.0%,12.4% and 4.0% respectively.Conclusion The intensity modulated radiation therapy（IMRT） combined with concurrent chemotherapy and RF hyperthermia might improve the 1,2,and 3 year overall survival rate in patients with ⅢB non-small-cell lung cancer.

关 键 词：调强适形放疗 长春瑞滨 顺铂 同步放化疗 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]