不同方法在纤维支气管镜刷检肺小细胞癌中的诊断价值  

The Clinical Value of Different Methods on Branchofiberoscope Specimens to Diagnose Small Cell Lung Cancer

作　　者：江涛[1] 朱立强[1] 朱玉秋[1] 叶涛[2] 方先勇[1] 

机构地区：[1]徐州医学院附属医院,221008 [2]徐州市肿瘤医院,221005

出　　处：《实用癌症杂志》2011年第5期496-497,共2页The Practical Journal of Cancer

摘　　要：目的探讨纤维支气管镜刷检中传统涂片法、液基细胞法及钳取活检法对原发性肺小细胞癌的诊断价值。方法对208例患者纤维支气管镜刷取和钳取的标本同时用传统涂片法、液基细胞法、钳取活检法进行诊断,将3种方法的结果进行比较分析。结果 208例原发性肺小细胞癌经纤维支气管镜刷检传统涂片法、液基细胞法、钳取活检法及液基细胞法+钳取活检法的阳性率分别为56.7%(118/208)、75.5%(157/208)、72.1%(150/208)、89.4%(186/208)。液基细胞法、钳取活检法的阳性检出率较传统涂片法高(P<0.01),联合液基细胞法和钳取活检法阳性检出率明显高于单一方法(P<0.01)。结论纤支镜刷检液基细胞法在诊断肺小细胞癌中具有一定的优势,联合钳取活检法可提高肺小细胞癌的阳性检出率,为临床提供科学的诊断依据。Objective To evaluate the clinical value of different methods including conventional smear,liquid-based cytology and biology to diagnose small cell lung cancer on the specimens obtained by branchofiberoscope.Methods The 208 cases of specimens obtained by branchofiberoscope were diagnosed by method of conventional smear,liquid-based cytology and biology at the same time,the positive rates were compared between them.Results The positive rates of conventional smear,liquid-based cytology and biology to diagnose 208 cases of primary small cell lung cancer were 56.7%（118/208）,75.5%（157/208）,72.1%（150/208）,respectively.The positive rates of liquid-based cytology and biology were higher than the conventional smear（P〈0.01）.The positive rate of combination of liquid-based cytology and biology was 89.4%,higher than any single methods（P〈0.01）.Conclusion Liquid-based cytology is superior to the conventional smear and biology.Combination of the liquid-based cytology and biology can increase the positive detection rate and provide more significant informations for clinical diagnosis.

关 键 词：肺小细胞癌 纤维支气管镜刷检 传统涂片 液基细胞 活检 诊断 

分 类 号：R734.2[医药卫生—肿瘤]