基于体素形态学测量对成人情绪记忆增强效应相关脑结构的初步研究  

A pilot study of voxel-based morphometry on brain structures related to emotional enhancement effect of memory

作　　者：宋文[1] 王海宝[1] 徐丽艳[1] 潘豪 吴津民[1] 余永强[1] 

机构地区：[1]安徽医科大学第一附属医院放射科,合肥230022

出　　处：《中华行为医学与脑科学杂志》2011年第9期840-842,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：安徽省自然科学基金项目（50430601）;安徽省教育厅自然科学重点项目基金项目（KJ2010A186）

摘　　要：目的采用基于体素形态学测量（VBM）和行为学相结合的方法，检测全脑容积及情绪记忆成绩，以探讨情绪记忆增强效应相关脑Ⅸ形态学特点。方法32名健康年轻人参加实验。试验过程包括情绪记忆行为学检测和磁共振扫描两个阶段，其中行为学检测包括记忆编码和再认，并记录行为学成绩。利用3．0T磁共振采集全脑容积数据。采用VBM5对全脑容积进行分割，获得脑灰质、脑白质和脑脊液容积。运用SPM5和SPSS13．0统计软件包进行相关统计分析。结果情绪图片再认正确率较中性图片正确率高（z=5．08，p〈0．01），增强效应明显（△Pr=0.12±0．01）；情绪记忆增强效应主要相关脑区包括双删杏仁核、额叶背外侧、额中回、前额叶背内侧、梭状回、右侧海马旁回、左侧眶回、中扣带回，并与双侧杏仁核容积率显著相关（左：r=0．564，P〈0．01，右：r=0．541，P〈0．01）。结论从脑形态结构水平证实了杏仁核等相关脑区是参与情绪记忆的重要脑结构，进一步扩展了功能成像的相关研究结果。Objective The brain volume and behavioral performance of emotional memory were measured by combining voxel-based morphometry （ VBM ） and behavior to explore the morphological characters of brain regions related to the emotional enhancement effect of memory. Methods A total of 32 healthy young subjects participated in the study. The experimental processes included MR scan and behavioral performance of emotional memory the latter of which involved two phases-encoding and retrieval. Behavioral performance was recorded and the whole-brain 3D MRI data were acquired via 3.0T MR. 3D MRI data were segmented by VBM5 ,and the wholebrain volumes of gray matter,white matter and CSF were produced. SPM5 and SPSS13.0 were used for statistical analysis of the 3D MRI data and behavioral data, respectively. Results Retrieval accuracy of the emotional pictures was higher than that of the neutral pictures （ t = 5.08, P〈 0. 001 ） ,the emotional enhancement effect was signifieant （ △Pr = 0.12 ±0.01 ）. Brain regions related to emotional enhancement effect included bilateral amygdala, dorsolateral prefrontal cortex, middle frontal gyrus, dorsomedial prefrontal cortex, fusiform gyrus, right parahipp- oeampus,left orbitofrontal cortex and middle cingulate gyrus. Volume ratio of bilateral amygda]a were related to emotion enhancement effect evidently （left： r=0.564, P〈0.01 ; right： r=0.541, P〈0.01 ）. Conclusion This study morphologically confirms that brain regions, such as amygdale and prefrontal cortex, are critical structures for the enhancement of emotional memory ,and further extends the findings of previous functional imaging studies.

关 键 词：情绪记忆 基于体素形态测量 脑容积 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]