三种常用中药注射液的过敏性研究  

Experimental Study on Allergy of Three Common TCM Injections

作　　者：王增仙[1] 武敏霞[1] 高萧枫[1] 李艳丽[1] 王明军[1] 李平[1] 

机构地区：[1]山西生物应用职业技术学院,山西太原030031

出　　处：《山西中医学院学报》2011年第4期5-7,共3页Journal of Shanxi College of Traditional Chinese Medicine

摘　　要：目的:探讨双黄连注射液、清开灵注射液和复方丹参注射液在皮肤被动过敏试验(PCA)和全身主动过敏试验(ASA)中是否有过敏反应。方法:按照《中药、天然药物免疫毒性(过敏性、光变态反应)研究的技术指导原则》的试验方法对以上3种注射液进行皮肤被动过敏试验和全身主动过敏试验研究。结果:皮肤被动过敏试验双黄连注射液有过敏反应;清开灵注射液高剂量组和低剂量组均出现过敏反应,其他组均未出现过敏反应。主动过敏试验双黄连注射液有4只动物过敏反应弱阳性,清开灵注射液高剂量组有1只动物过敏反应弱阳性。结论:对于双黄连注射液、清开灵注射液2种注射液而言,临床用药前均应做皮肤被动过敏试验。Objective：To observe skin allergy,general allergical reaction effect of Shuanghuanglian injection,Qingkailing injection and compound Danshen injection on rats,guinea pig respectively.Methods：Passive cutaneous anaphylaxis（PCA） and ASA were carried out to study the allergy of three kinds of injections of TCM.Result：The rats exhibited allergic reaction in Shuanghuanglian injection group,Qingkailing injection high dose group and low dose group during PCA test.Weak reactions of Shuanghuanglian and Qingkailing injection were found in 4 guinea pigs and 1 guinea pig respectively.Conclusion：PCA test should be carried on to all patients before clinical use for shuanghuanglian and Qingkailing injections.

关 键 词：双黄连注射液 清开灵注射液 复方丹参注射液 皮肤被动过敏性试验 全身主动过敏试验 

分 类 号：R285.6[医药卫生—中药学]