胃癌组织中Livin与Caspase-9的表达及临床意义  

Expression and clinical significance of Livin and Caspase-9 in gastric carcinoma tissue

作　　者：刘满华[1] 田蕾[1] 郭连怡[1] 李舒[1] 

机构地区：[1]辽宁医学院附属第一医院消化内科,辽宁锦州121000

出　　处：《中国老年学杂志》2011年第18期3454-3456,共3页Chinese Journal of Gerontology

基　　金：辽宁省教育厅2009年度高等学校科研计划项目(2009A474)

摘　　要：目的研究Livin和Caspase-9在人体胃癌组织中的表达,初步探讨二者与胃癌生物学行为的关系以及二者之间的相关性。方法采用免疫组织化学SP法检测78例胃癌组织中Livin和Caspase-9的表达,30例胃溃疡患者胃黏膜组织作为对照。结果胃癌组织中Livin的表达率显著高于对照胃黏膜组织,Caspase-9的表达率则低于对照胃黏膜组织,差异均具有统计学意义(P<0.01)。Livin与Caspase-9的表达呈负相关(P<0.01,r=-0.304),二者的阳性表达率与肿瘤浸润深度、淋巴结转移、临床分期及肿瘤病理分化程度密切相关,与性别、年龄、肿瘤大小无相关性(P>0.05)。结论 Livin和Caspase-9参与胃癌的发生、发展,二者表达呈负相关。Livin和Caspase-9有可能成为胃癌临床诊断、判断疗效及监测预后的可靠指标。Objective To study the expression of Livin and Caspase-9 in human gastric carcinoma tissue and explore the relationship between their expressions and clinical pathology parameters and correlation between Livin and Caspase-9 expression.Methods The expressions of Livin and Caspase-9 were detected by immunohistochemical technique（streptavidin-peroxidase） in 78 gastric carcinoma tissues and 30 gastric ulcers.Results The positive expression rate of Livin in gastric carcinoma tissues was significantly higher than that of gastric ulcers,and the expression of Caspase-9 was lower than that of gastric ulcers（P 0.01）.The expression of Livin was negatively correlated with the expression of Caspase-9（P 0.01,r =-0.304）.The expression of Livin and Caspase-9 was closely correlated with tumor depth of gastric cancer,lymph nods metastasis,clinical stages and histological differentiation grade,but not with sex,age and tumor size（P 0.05）.Conclusions Livin and Caspase-9 are associated with occurrence and development of gastric cancer,and the expression of the above two are negatively correlated.Livin and Caspase-9 may be considered as reliable markers for clinical diagnosis,therapy efficacy and the prognosis of gastric carcinoma.

关 键 词：LIVIN CASPASE-9 胃癌 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]