血管紧张素转移酶基因插入/缺失多态性与胃癌的相关性  

The association between ACE polymorphism and risk of gastric cancer

作　　者：史美龙[1] 邵红[2] 鲁海宏[3] 张景斌[1] 

机构地区：[1]吉林省人民医院普外科,吉林长春130021 [2]吉林省人民医院内分泌科 [3]九台市中医院

出　　处：《中国老年学杂志》2011年第18期3526-3528,共3页Chinese Journal of Gerontology

基　　金：吉林省科技厅资助项目(20100753)

摘　　要：目的探讨血管紧张素转移酶(ACE)基因插入(I)/缺失(D)多态性与胃癌的相关性。方法采用聚合酶链反应(PCR)法检测181例胃癌组和198例健康对照组ACE基因I/D多态性。结果胃癌组与对照组ACE I/D基因型和等位基因分布差异不显著(P>0.05)。根据临床特征进行亚组分析,发现低分化胃癌患者中DD基因型频率明显高于高中分化(P=0.002);有转移的胃癌患者中DD基因型频率明显高于未转移(P=0.012)。结论 ACE基因I/D多态性与胃癌的分化程度和转移状态等影响胃癌预后的临床病理特征密切相关。Objective To investigate the association between ACE I/D polymorphism and the risk of gastric cancer.Methods The genotype of ACE I/D polymorphism was determined in 181 patients with gastric cancer and 198 healthy controls using polymerase chain reaction strategy.Results Patients carrying DD genotype were associated with an increased risk of developing poorly differentiated cancer and metastasis compared with those carrying Ⅱ genotype（P=0.002,and P=0.012,respectively）,although no significant association was observed between cases and controls in overall analysis.Conclusions The ACE I/D polymorphism is associated with clinical features of gastric cancer,including differentiation grade,and metastasis status.

关 键 词：血管紧张素转移酶基因 插入/缺失多态性 胃癌 

分 类 号：R394[医药卫生—医学遗传学]