纳美芬对脑肿瘤术后的脑保护作用  

Brain protective efficacy of nalmefene for patients with brain tumor undergone operation

作　　者：胡枢坤[1] 黄峰平[1] 郑康[1] 

机构地区：[1]复旦大学附属华山医院神经外科,上海市200040

出　　处：《国际神经病学神经外科学杂志》2011年第4期319-322,共4页Journal of International Neurology and Neurosurgery

摘　　要：目的探讨纳美芬对脑肿瘤手术后病人的治疗效果。方法 312例脑肿瘤手术的病人,随机、单盲分为治疗组和对照组,治疗组160例,对照组152例。对照组予常规治疗,治疗组在常规治疗的基础上加用纳美芬治疗5天,治疗后3,7,14和90天予格拉斯哥昏迷评分(GCS)和barthel评分,治疗后90天予Karnofsky评分进行远期疗效评价。结果治疗后3天和90天,治疗组GCS评分好于对照组。治疗后14天和90天,barthel评分提示治疗组神经功能改善率高于对照组。治疗后90天Karnofsky评分优于对照组。未见明显不良反应。结论纳美芬对脑肿瘤手术后的患者可能具有脑保护的作用。Objective To evaluate the efficacy and safety of nalmefene in the postoperative treatment of patients with brain tumor.Methods 312 patients with brain tumors operated were randomly divided into treatment and control groups.Treatment group has 160 patients and control group has 152 patients.The control group received conventional therapy,and the treatment group was administered with nalmefene injection for 5 days beside the conventional therapy.The therapeutic effects were evaluated by the GCS 3,7,14 and 90 days after treatment.The neurological function was evaluated by the Barthel Index（BI） 3,7,14 and 90 days after treatment.The long-term prognosis was evaluated by the Karnofsky Index 90 days after treatment.Results The GCS score in the treatment group was significantly higher than that in the control group 3 and 90 days after treatment（P0.05）.After treatment,the BI indicated a higher recovery rate in the treatment group than controls（P0.05） in day 14 and 90.the Karnofsky Index shows better clinical prognosis in the treatment group（P0.05） 90 days after treatment.No adverse events were found.Conclusions Nalmefene is an effective and safe treatment for patients with brain tumor operated.

关 键 词：纳美芬 脑肿瘤 意识 神经功能 

分 类 号：R739.4[医药卫生—肿瘤]