法舒地尔在肝癌血管介入治疗中的应用  

The application of Fasudil in treating vascular spasm occurred in interventional treatment for hepatocellular carcinomas

作　　者：范晓强[1] 沈杰[1] 张雪娜[1] 刘秋如[1] 马爱英[1] 

机构地区：[1]解放军第四五五医院肝肿瘤诊疗中心,上海200052

出　　处：《介入放射学杂志》2011年第9期740-742,共3页Journal of Interventional Radiology

摘　　要：目的探讨解除肝癌介入化疗栓塞过程中血管痉挛的方法。方法肝癌栓塞化疗过程中,痉挛血管近侧局部经导管推注法舒地尔2.5 mg,然后行DSA造影确定血管扩张情况,同时观察并记录其不良反应。结果 30例次血管痉挛给予法舒地尔后全部解除,顺利完成超选择插管并给予足量超液化碘油充填,患者无特殊不适主诉。结论导管内推注法舒地尔可有效解除肝动脉分支痉挛,效果显著,成功率高,安全性好,值得临床推广。Objective To explore an effective way to treat the vascular spasm occurred during TACE for hepatocellular carcinomas.Methods During interventional chemoembolization for hepatocellular carcinomas,Fasudil of 2.5mg was injected via the catheter if vessel spasm occurred,which was followed by DSA to determine the dilatation of the arteries.Adverse effect was observed and recorded.Results After the injection of Fasudil the vascular spasm was completely relieved in all the 30 cases.The interventional procedure for hepatocellular carcinomas was successfully accomplished in all patients.No obvious side effect occurred.Conclusion The injection of Fasudil via the catheter is an effective and safe method to eliminate vessel spasm occurred during TACE for hepatocellular carcinomas.

关 键 词：肝癌 经肝动脉化疗栓塞 血管痉挛 法舒地尔 

分 类 号：R735.7[医药卫生—肿瘤]