普萘洛尔治疗增生期血管瘤患儿血清中血管内皮生长因子及基质金属蛋白酶-9的变化  

The change of serum vascular endothelial growth factor and matrix metalloproteinases-9 in proliferative hemangioma treated with propranolol

作　　者：赵忠芳[1] 吕仁荣[2] 霍然[2] 傅洪滨[2] 徐广琪[2] 马少林[1] 

机构地区：[1]新疆医科大学第一附属医院烧伤整形科,乌鲁木齐830054 [2]山东大学附属省立医院烧伤整形美容外科

出　　处：《中华整形外科杂志》2011年第5期359-361,共3页Chinese Journal of Plastic Surgery

基　　金：山东省科学技术发展计划（第一批）医药卫生项目（2010GSF10266）

摘　　要：目的研究普萘洛尔口服治疗增生期血管瘤，及对血清中血管内皮生长因子（vascularendothelialgrowthfactor，VEGF）、基质金属蛋白酶-9（matrixmetalloproteinase-9，MMP-9）水平的影响。方法采用ELISA法检测患者服药4、8周后血清VEGF、MMP．9水平，并分析其与预后的关系。结果治疗前血清VEGF水平最高，而服药后4周（255．7±130．4）和服药后8周（224．24-120．6）VEGF水平呈逐渐下降趋势，治疗后8周VEGF水平显著低于治疗前（P〈0．05）。MMP-9的表达变化与VEGF一致，并与VEGF呈正相关。结论普萘洛尔可以通过降低患者血清VEGF和MMP-9水平，从而治疗增生期血管瘤。Objective To study the level metalloproteinases-9 in the proliferative hemangioma of serum vascular endothelial growth factor, matrix before and after propranolol treatment. Methods The serum VEGF, MMP-9 was detected with ELISA assay before treatment and after 4 weeks and 8 weeks of propranolol treatment. The relationship between the serum VEGF, MMP-9 and the prognosis was analyzed. Results The serum VEGF（295.4 ± 158. 1） pg/ml was high before treatment, then decreased after 4 weeks and 8 weeks of treatment （255. 7 ± 130.4） pg/ml, （224. 2± 120. 6） pg/ml. The serum VEGF was significantly lower after 8 weeks of treatment（ P 〈 0.05 ）. The serum MMP-9 was also decreased after treatment, showing a positive relationship with VEGF. Conclusions Propranolol can treat the proliferative hemangioma through decreasing the serum VEGF and MMP-9.

关 键 词：婴幼儿血管瘤 普萘洛尔 血管内皮生长因子 基质金属蛋白酶-9 

分 类 号：R739.5[医药卫生—肿瘤]