NF-κB、MMP-2在非小细胞肺癌中的表达  

Expression and clinicopathologic significance of NF-κBp65 and MMP-2 in non-small cell lung cancer

作　　者：路会玲[1] 王翎[2] 

机构地区：[1]苏州市立医院,江苏苏州215001 [2]苏州大学附属第一医院,江苏苏州215000

出　　处：《临床肺科杂志》2011年第11期1740-1742,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨核因子-κB(NF-κBp65)和基质金属蛋白酶-2(MMP-2)在非小细胞肺癌(NSCLC)中的表达及临床意义。方法免疫组化法检测70例NSCLC和11例正常肺组织中NF-κBp65和MMP-2的蛋白表达水平。结果 NF-κBp65和MMP-2在NSCLC中阳性率分别为61.43%、52.86%,在正常肺组织中表达阳性率分别为9.09%、18.18%。NSCLC中NF-κBp65、MMP-2表达明显高于正常组织(P<0.05)。NF-κBp65和MMP-2的表达率与患者的淋巴结转移、TNM分期有密切关系;NF-κBp65和MMP-2为负性预后因子;NF-κBp65和MMP-2之间呈正相关。结论 NF-κBp65和MMP-2在肺癌中高表达,NF-κBp65和MMP-2阳性表达提示预后不良。Objective To explore the expression of NF-κBp65 and MMP-2 in non-small cell lung cancer and their clinical significance.Methods To detect proteins expression levels of NF-κBp65 and MMP-2 in 70 cases of non-small cell lung cancers and 11 cases of normal lung tissues.Results The positive expression rates of NF-κBp65 and MMP-2 were 61.43%and 52.86% respectively in the 70 non-small cell lung cancers,and 9.09% and 18.18% respectively in 11 normal lung tissues.The protein expression of NF-κBp65 and MMP-2 were significantly correlated with lymph node metastasis and clinical stages.NF-κBp65 and MMP-2 would be the negative prognostic factors.There were positive correlations between NF-κBp65 and MMP-2.Conclusion Over-expressions of NF-κBp65 and MMP-2 in non-small cell lung cancer,the positive expressions of NF-κBp65 and MMP-2 predicate the poor prognosis.

关 键 词：核因子-ΚB 基质金属蛋白酶-2 非小细胞肺癌 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]